Microwave facilitated one-pot three component synthesis of coumarin-benzoxazole clubbed 1,2,3-triazoles: Antimicrobial evaluation, molecular docking and in silico ADME studies

Cu (Ι) catalyzed A3 cascade coupling via C‐H functionalization followed by cyclization: Synthesis, in silico, in vitro, and toxicity studies of imidazo[2,1‐b]thiazoles

“…Antibacterial activities of the synthesized compounds were assessed in vitro by agar well diffusion method against bacteria E. coli and S. aureus . [ 40 ] Figure 15 illustrates the zone of inhibition owing to the consequence of synthesized compounds on the bacteria, whereas Figures 16 and 17 correspond to the graph concerning the comparative antibacterial activities of the compounds 7j–x exhibiting different MICs and ZOIs, respectively. An enhancement in the size of the zone of inhibition was perceived for all bacterial strains tested with synthesized compounds signifying their antibacterial activity.…”

“…Antibacterial activities of the synthesized compounds were assessed in vitro by agar well diffusion method against bacteria E. coli and S. aureus. [40] Figure 15 illustrates the zone of inhibition owing to the consequence of synthesized compounds on the bacteria, whereas The results of assays are summarized in Table 7.…”

Synthesis and Characterization of Some Novel Heteroannulated Chromeno[4,3-b]quinolines

“…3 An interesting framework for creating new anti-inflammatory medicines is widely provided by coumarin derivatives. 4 The biological uses of coumarins include antioxidant, 5 anti-HIV, 6 antiviral, 7 antibacterial, 8 antimalarial, 9 antifungal, 10 anti-influenza, 11 antimicrobial, 12 antiproliferative, 13 anticoagulant, 14 antileishmanial, 15 antiplatelet, 16 and antidepressant. 17 Computational studies are used to investigate and recognize the structural, vibrational and optical properties using DFT calculations.…”

Chitosan‐ZnO: An Efficient and Recyclable Polymer Incorporated Hybrid Nanocatalyst to Synthesize Tetrahydrobenzo[b]pyrans and Pyrano[2,3‐d]pyrimidinones under Microwave Expedition

“…In this perspective, multicomponent reaction (MCR) has evolved as an essential strategy in organic synthesis over multistep reactions. MCRs are also beneficial for the practical constitution of chemical libraries of structurally related, medicinally important drug likecompounds [23,24] including reduction in the chemical waste, diminished reaction times and furnish higher overall chemical yields [25–28] …”

“…[20] Owing to the existence of heterocyclic entities in various natural products and their application in pharmacological fields, [21,22] chemists are more intended in the synthesis of such molecules in proficient approach. In this perspective, multicomponent reaction (MCR) has evolved as an essential strategy in organic synthesis over multistep reactions.MCRs are also beneficial for the practical constitution of chemical libraries of structurally related, medicinally important drug likecompounds [23,24] including reduction in the chemical waste, ChemistrySelect ChemistrySelect diminished reaction times and furnish higher overall chemical yields. [25][26][27][28] 4H-Chromene derivatives display pharmaceutical properties such as hypotensive, antimicrobial, antitumor, antileishmanial, anti-HIV and local anaesthetic agents.…”