The genus Macaranga belongs to the family Euphorbiaceaeconsistingof about 300 species that are mainly distributed inthe tropics of Africa, Asia, Australia, and the Pacific regions. Thirteen different species of this genus occur in Viet Nam, and Macaranga sampsonii has been used in traditional medicine to treat swellings, cuts, sores. Phytochemical investigation of the methanol extract of Macaranga sampsonii led to the isolation of six compounds including: boehmenan X (1), maltol β‐D‐glucopyranoside (2), methyl brevifolincarboxylate (3), scopoletin (4), 3,5‐dihydroxy‐4‐methoxy benzoic acid (5) and gallic acid (6). Their structures were confirmed by spectroscopic methods including IR, MS, 1D, 2D NMR and compared to previous reported spectral data values.
Macaranga denticulata is a 15‐18 m tall plant with rounded edges and long, rounded bark, 5 mm wide black covered with glands. In traditional medicine, this plant was used to treat fulminant hepatitis, dysentery, and urinary retention. In previous studies, we reported 13 isolated compounds from the fruits of Macaranga denticulata. This work presented the isolation and structural characterizations of seven compounds: 5‐((E)‐3,5‐dihydroxystyryl)‐3‐((E)‐3,7‐dimethylocta‐2,6‐dien‐1‐yl)benzen‐1,2‐diol (1), poilaneic acid (2), stigmast‐4‐en‐6β‐ol‐3‐one (3), epi‐taraxerol (4), rel‐5‐(3S,8S‐dihydroxy‐1R,5S‐dimethyl‐7‐oxa‐6‐oxobicyclo[3,2,1]‐oct‐8‐yl)3‐methyl, 2Z,4E‐pentadienoic acid (5), ellagic acid 3,3'‐dimethyl ether‐4‐O‐β‐D‐glucopyranoside (6), 3‐hydroxypropanoic acid (7). The structures of the isolated compounds were elucidated from their mass and NMR spectral data.
In the course of our screening program, the EtOAc extract of a Micromonospora sp. (strain G044) from sponge Tethya aurantium of the sea of Côtô -Thanh Lân exhibited antimicrobial activity against Enterococcus faecalis, Bacillus cereus and Candida albicans. In this paper, we reported the isolation and structural elucidation of six secondary metabolites Cyclo-(Pro-Trp) (1), Cyclo-(Pro-Met) (2), Cyclo-(Pro-Val) (4), N-acetyltryptamine (3), uridine (5), and 2-phenylacetic acid (6) from the cultures broth of Micromonospora sp. (strain G044). The structures of 1 -6 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compound 1 inhibited Escherichia coli with a MIC value of 128 µg/ml.
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