Antimicrobial Secondary Metabolites from the Marine-Derived Fungus Aspergillus sp. M28

Minh, Le Quoc; Huệ, Nguyễn Thị; Linh, Nguyễn Thùy; Ngan, Truong Bich; Quyên, Vũ Thị; Anh, Nguyễn Mai; Tuan, Cao Duc; Minh, Châu Văn; Cường, Phạm Văn; Hương, Đoàn Thị Mai

doi:10.1007/s10600-020-03259-w

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“…is an endophytic fungus and has received considerable attention of researchers in recent years. 1 Aspergillus fumigatus, an endophyte found in portunus, plants, and others, has an outstanding ability of synthesizing primary and secondary bioactive metabolites. The secondary metabolites biosynthesized by A. fumigatus have shown multiple biological activities for common human diseases.…”

Section: Introductionmentioning

confidence: 99%

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Induced effect of Ca²⁺ and Al³⁺ on chaetominine synthesis by Aspergillus fumigatus CY018 under submerged fermentation

Liu

Chen²,

Chen

et al. 2022

Biotech and App Biochem

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Chaetominine (CHA), an alkaloid with biological activity produced by Aspergillus fumigatus CY018, has strong anticancer activity against the human leukemia cell. However, its further research for pharmacokinetics is limited by CHA production in submerged fermentation, which is a problem urgently awaiting solutions by effective biological strategies. In this work, Ca 2+ and Al 3+ exhibited a strong promoting effect on CHA production after multiple metal ions screening. Then, the concentration of Ca 2+ and Al 3+ and the addition time was optimized. The suitable conditions were 0.5 mM Ca 2+ and 0.5 mM Al 3+ at 120 h, in which the CHA production reached 58.5 and 49.45 mg/L with optimized condition of Ca 2+ and Al 3+ respectively. The intermediate metabolites, such as DAHP, chorismate and tryptophan, were increased obviously with addition of Ca 2+ and Al 3+ . The activities of key enzymes of DAHPs, AroAs and TrpCs in CHA biosynthesis pathway were improved by 3.58-, 3.60-and 3.34-folds respectively. Meanwhile, the transcription levels of laeA, dahp, cs, and trpC were upregulated by 3.22-, 12.65-, 5.58-and 6.99-fold respectively by addition of Ca 2+ and Al 3+ . Additionally, the fermentation strategy was successfully scaled up to 5 L reactor, in which CHA production could attain 75.6 mg/L at 336 h. This work demonstrated that Ca 2+ and Al 3+ co-addition was an effective strategy for increasing CHA production, and the information obtained might be useful to the further improvement of CHA fermentation on large scale.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Aspergillus sp. is an endophytic fungus and has received considerable attention of researchers in recent years 1 . Aspergillus fumigatus , an endophyte found in portunus, plants, and others, has an outstanding ability of synthesizing primary and secondary bioactive metabolites.…”

Section: Introductionmentioning

confidence: 99%

Induced effect of Ca²⁺ and Al³⁺ on chaetominine synthesis by Aspergillus fumigatus CY018 under submerged fermentation

Liu

Chen²,

Chen

et al. 2022

Biotech and App Biochem

View full text Add to dashboard Cite

show abstract

Antimicrobial Secondary Metabolites from the Marine-Derived Fungus Aspergillus sp. M28

Cited by 1 publication

References 18 publications

Induced effect of Ca²⁺ and Al³⁺ on chaetominine synthesis by Aspergillus fumigatus CY018 under submerged fermentation

Induced effect of Ca²⁺ and Al³⁺ on chaetominine synthesis by Aspergillus fumigatus CY018 under submerged fermentation

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Antimicrobial Secondary Metabolites from the Marine-Derived Fungus Aspergillus sp. M28

Cited by 1 publication

References 18 publications

Induced effect of Ca2+ and Al3+ on chaetominine synthesis by Aspergillus fumigatus CY018 under submerged fermentation

Induced effect of Ca2+ and Al3+ on chaetominine synthesis by Aspergillus fumigatus CY018 under submerged fermentation

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Product

Resources

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Induced effect of Ca²⁺ and Al³⁺ on chaetominine synthesis by Aspergillus fumigatus CY018 under submerged fermentation

Induced effect of Ca²⁺ and Al³⁺ on chaetominine synthesis by Aspergillus fumigatus CY018 under submerged fermentation