Chemical constituents of MeOH extract from the fruits of <i>Macaranga sampsonii</i>

Quynh, Do Thi; Vu, Le Tran Nguyen; Hương, Đoàn Thị Mai; Ngan, Truong Bich; Huệ, Nguyễn Thị; Thach, Tran Dang; Cường, Phạm Văn

doi:10.1002/vjch.201800052

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…The liver function of experimental rats was assessed based on the levels of ALT, AST, and ALP in the serum ( [22], evolitrine (4) [23], and pachypodol (5) [24]. Compounds 1, 2, and 4 were isolated for the first time from M.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Antidiabetic effect of Melicope glabra¬ (Blume) T. G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components

Quek¹,

Tan²,

Lim³

et al. 2022

JFB

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Melicope glabra (Blume) T. G. Hartley is a plant of Rutaceae family. The present study aimed to evaluate the in vivo hypoglycemic effect of M. glabra leaves extract on diabetic rats and identify its bioactive components. The induction of diabetes in Sprague-Dawley rats was done by a combination of high-fat diet and low-dose streptozotocin injection. The M. glabra extracts and standard sitagliptin were orally administered once daily to the diabetic rats for 28 days. The diabetic rats showed drastic weight loss, hyperglycemia, poor glucose tolerance, hyperlipidemia, and disturbances in the liver and kidney functions. However, oral administration of M. glabra extracts to the diabetic rats significantly lowered the DPP-4 level and increased glucagon-like peptide-1 (GLP-1) level. Scopoletin, pachypodol, and stigmasterol were revealed as the active DPP-4 and α-amylase inhibitors. This study revealed novel findings which suggest the

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Section: Accepted Manuscriptmentioning

confidence: 99%

Antidiabetic effect of Melicope glabra¬ (Blume) T. G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components

Quek¹,

Tan²,

Lim³

et al. 2022

JFB

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“…Whereas the fresh leaves were used to cover wounds, a decoction from the dried root was administered against cough and fever (Kamarozaman et al, 2018;Phommart et al, 2005, Phupattanapong andWongprasert, 1987). M. sampsonii Hance has been used for the treatment of swellings, cuts and sores (Quynh et al, 2018). The European expeditioners surveying the traditional medicinal plants of Papua New Guinea islands recorded the use of M. aleuritoides F. Muell.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia

Leláková

Béraud-Dufour

Hošek

et al. 2020

Journal of Ethnopharmacology

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Ethnopharmacological relevance-Macaranga Thou. (Euphorbiaceae) is a large genus that comprises over 300 species distributed between Western Africa and the islands of the South Pacific. Plants of this genus have a long-standing history of use in traditional medicine for different purposes, including the treatment of inflammation. Fresh and dried leaves of certain Macaranga species (e.g. M. tanarius (L.) Müll.Arg.), have been used to treat cuts, bruises, boils, swellings, sores and covering of wounds in general. Several reports described Macaranga spp. being a rich source of polyphenols, such as prenylated stilbenes and flavonoids, mostly responsible for its biological activity. Similarly, an abundant content of prenylated stilbenes was also described in M. siamensis S. J. Davies, species recently identified ( 2001) in Thailand. While the respective biological activity of the prenylated stilbenes from M. siamensis was poorly investigated to date, our recent study pointed out the interest as the natural source of several novel anti-inflammatory stilbenoids isolated from this species. Aim of the study-Thiswork investigated the potential anti-inflammatory effects of the stilbenoid macasiamenene F (MF) isolated from M. siamensis S.J. Davies (Euphorbiaceae) on the lipopolysaccharide (LPS)-induced inflammation of monocytes and microglia, major cells involved in the peripheral and central inflammatory response, respectively. Materials and methods-LPS-induced stimulation of TLR4 signaling led to the activation of inflammatory pathways in in vitro models of THP-1 and THP-1-XBlue™-MD2-CD14 human monocytes, BV-2 mouse microglia, and an ex vivo model of brain-sorted mouse microglia. The ability of the stilbenoid MF to intervene in the IкB/NF-кB and MAPKs/AP-1 inflammatory cascade was investigated. The gene and protein expressions of the proinflammatory cytokines IL-1β and TNF-α were evaluated at the transcription and translation Page 3 of 43 levels. The protective effect of MF against LPS-triggered microglial loss was assessed by cell counting and an LDH assay.Results-MF demonstrated beneficial effects, reducing both monocyte and microglial inflammation as assessed in vitro. It efficiently inhibited the degradation of IкBα, thereby reducing the NF-кB activity and TNF-α expression in human monocytes. Furthermore, the LPS-induced expression of IL-1β and TNF-α in microglia was dampened by pre-, co-, or post-treatment with MF. In addition to its anti-inflammatory effect, MF demonstrated a cytoprotective effect against the LPS-induced death of BV-2 microglia. Conclusion-Our research into anti-inflammatory and protective effects of MF has shownthat it is a promising candidate for further in vitro and in vivo investigations of MF intervention with respect to acute and chronic inflammation, including potentially beneficial effects on the inflammatory component of brain diseases such as stroke and Alzheimer's disease.

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Conglomeratin: a new antibacterial flavonol derivative from Macaranga conglomerata Brenan (Euphorbiaceae)

Ibrahim

Onyari

Omosa

et al. 2022

Natural Product Research

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A new prenylated kaempferol, conglomeratin (1), alongside 7 known compounds including flavonoids (2 and 3), ellagic acid derivatives (4 and 5), triterpenoids (6 and 7), and a coumarin (8) were isolated from the leaves (1 -5) and stem bark (6 -8) of Macaranga conglomerata. Their structures were elucidated using spectroscopic and spectrometric techniques. The antibacterial assay was performed using disc diffusion method against Gram-positive and Gram-negative microorganisms. Compound 1 was significantly active against Pseudomonas aeruginosa ATCC 27853 (MIC = 7.8 g/mL) and moderately active towards Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 31488 (MIC = 62.5 g/mL).Compound 2 showed potency against P. aeruginosa ATCC 27853 (MIC = 1.0 g/mL) while 4 and 7 were selective towards K. pneumoniae ATCC 31488 (MIC = 7.8 and 1.0 g/mL, respectively). These findings suggest that prenylation of flavonoids may contribute to improving their broadspectrum antimicrobial activities.

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Chemical constituents of MeOH extract from the fruits of Macaranga sampsonii

Cited by 3 publications

References 7 publications

Antidiabetic effect of Melicope glabra¬ (Blume) T. G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components

Antidiabetic effect of Melicope glabra¬ (Blume) T. G. Hartley (Rutaceae) in high-fat diet/streptozotocin-induced diabetic rats and its bioactive components

Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia

Conglomeratin: a new antibacterial flavonol derivative from Macaranga conglomerata Brenan (Euphorbiaceae)

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