Objective: To determine the phytochemical analysis and anti-inflammatory effect of the aqueous extract of Tabernaemontanadivaricata flower in Wister Rats.Methods: The aqueous extract of fresh flowers of the plant Tabernaemontanadivaricata (family-Apocyanaceae) were prepared and analyzed for phytochemical constituents using standard methods. The anti-inflammatory activity of the plant extracts was examined with the help of rat models by taking diclofenac as a standard drug against T. divericata oil extract by using carrageenan induced rat paw edema method with the help of the instrument plethesmometer.Results: The present experiment shows the phytochemical analysis, anti-inflammatory activity of the aqueous extract of fresh flowers of the plant Tabernaemontanadivaricata (family-Apocyanaceae). Various phytochemical analysis revealed the presence of saponins, flavonoids, glycosides, steroids, proteins, phenols, amino acids and tannins. The oil extract of the plant showed much effective anti-inflammatory activity against the standard drug.Conclusion: It can be concluded aqueous extract of the flower of the plant Tabernaemontanadivaricata (family-Apocyanaceae) contain the high presence of phytochemicals. This extract was found to possess promising antimicrobial activity when compared with the standards.
The primary objective of the present investigation is to evaluate the antihyperglycemic activity of the 50% ethanolic extract of the Tecomella undulata Seem. (TUE) bark in the streptozotocin induced diabetic rats. Methods: Single intraperitoneal injection (i.p.) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes is wistar albino rats. The induction of diabetes was confirmed after 3 days after STZ injection and rats with fasting blood glucose levels greater than 200 mg/dl were considered to be diabetic used in the experiment. TUE at a once a daily dose of 250 mg/kg, and 500 mg/kg, p.o. along with glibenclamide 600µg/kg, p.o. was also given for 21 days. On the 21 st day rats from all the groups fasted overnight and the blood was collected from the puncturing the retro orbit of the eye under mild ether anesthetic condition. The oral acute toxicity studies did not show any toxic effect till the dose at 2000 mg/kg. Results: The statistical data indicated that the different doses of the TUE significantly decreases the level of fasting blood glucose, total cholesterol, triglycerides, low density lipoprotein and increase high density lipoprotein in STZ induced diabetic rats. This result indicated that T. undulata extract can protect pancreatic βcells from STZ-induced damage which is confirmed by the results of the histopathological examination of the pancreas. Conclusion: Our investigation has clearly indicated that the bark extract of Tecomella undulata Seem. showed remarkable antihyperglycemic activity due to its possible systematic effect involving in the pancreatic and extra pancreatic mechanism. Moreover, the antihyperlipidemic activity was exerted possible by lowering the higher level of lipid profile.
Objective: To evaluate the antimicrobial activity ethanolic extracts of stems of the plant Ipomoea aquatica Forsk. (family-Convolvulaceae) along with preliminary phytochemical analysis. Methods:The ethanolic extract of stems of the plant Ipomoea aquatica Forsk. (family-Convolvulaceae) were prepared and analyzed for phytochemical constituents using standard methods. The antimicrobial activity of the plant extracts was examined against 2 bacterial strains among one is gram positive and other is gram negative and 2 fungus using agar well diffusion method.Results: The present experiment shows the phytochemical analysis, antimicrobial activity of the ethanolic extract of stems of the plant Ipomoea aquatic Forsk. (Family-Convolvulaceae). Various phytochemical analysis revealed the presence of alkaloids, saponin, flavonoids, carbohydrates, glycosides, Steroids, proteins and amino acids and tannins. All the extracts of the plant showed antimicrobial activity against most of the test organisms. Conclusion:The present study concluded that ethanolic extract of stems of the plant Ipomoea aquatica Forsk. Contain the high presence of phytochemical. The ethanolic extract of the plant was found to possess promising antimicrobial activity when compared with the standards.
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