The primary objective of the present investigation is to evaluate the antihyperglycemic activity of the 50% ethanolic extract of the Tecomella undulata Seem. (TUE) bark in the streptozotocin induced diabetic rats. Methods: Single intraperitoneal injection (i.p.) of streptozotocin (60 mg/kg body weight) was used for induction of diabetes is wistar albino rats. The induction of diabetes was confirmed after 3 days after STZ injection and rats with fasting blood glucose levels greater than 200 mg/dl were considered to be diabetic used in the experiment. TUE at a once a daily dose of 250 mg/kg, and 500 mg/kg, p.o. along with glibenclamide 600µg/kg, p.o. was also given for 21 days. On the 21 st day rats from all the groups fasted overnight and the blood was collected from the puncturing the retro orbit of the eye under mild ether anesthetic condition. The oral acute toxicity studies did not show any toxic effect till the dose at 2000 mg/kg. Results: The statistical data indicated that the different doses of the TUE significantly decreases the level of fasting blood glucose, total cholesterol, triglycerides, low density lipoprotein and increase high density lipoprotein in STZ induced diabetic rats. This result indicated that T. undulata extract can protect pancreatic βcells from STZ-induced damage which is confirmed by the results of the histopathological examination of the pancreas. Conclusion: Our investigation has clearly indicated that the bark extract of Tecomella undulata Seem. showed remarkable antihyperglycemic activity due to its possible systematic effect involving in the pancreatic and extra pancreatic mechanism. Moreover, the antihyperlipidemic activity was exerted possible by lowering the higher level of lipid profile.
The essential oil from the dried leaves of Eupatorium odoratum Linn. was obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). The major components were α-pinene (9.64 %), β-pinene, (4.85 %), germacrene D (20.27 %) , geijerene (25.10 %), trans-βcaryophyllene (10.04 %), and other components were presents in trace quantities. The leaf oil was screened for in vitro antibacterial activity and was tested against both gram positive and gram negative bacterial strains.The essential oil was found to be more active against E. coli (MIC = 125 μg/ml) and B .Subtilis (MIC = 62.5 μg/ml) respectively.
Vyanga (Melasma) is a condition of localized hypermelanosis which affects face, and continues to be a challenging problem as it causes immense mental stress and depression. Although various products are available in the market for the management of Vyanga, they have some adverse side effects, particularly towards pregnant and lactating mothers. Their prolong use in other normal persons also leaves side effects. Therefore there is a need to look for more efficacious agents with lesser side effects. In the Ayurvedic classics there was mention of Vyanga which was described under kshudra roga of twaka roga which can be compared with today's melasma. It was found that a huge number of herbal medicines as well as shastra karma were described in classics for treatment of Vyanga. Among the herbs, I selected Manjistha (Rubia cordifolia) and Arjuna (Terminalia arjuna) as my drug of choice. The clinical efficacy of the combination was evaluated in 100 patients of Vyanga. Improvement was assessed on the basis of classical sign and symptoms as per pre-defined scores, laboratory investigations and photographs. The improvements in various subjective sign and symptoms were evaluated in terms of percentage improvement. In the study 98% patients got complete improvement in subjective parameters by the use of Manjistha (Rubia cordifolia) along with Arjuna (Terminalia arjuna) in both ointment and tablet form.
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