The association of daily cardiac and respiratory admissions to 168 acute care hospitals in Ontario, Canada, with daily levels of particulate sulfates was examined over the 6-year period 1983-1988. Sulfate levels were recorded at nine monitoring stations in regions of southern and central Ontario spanned by three monitoring networks. A 13-micrograms/m3 increase in sulfates recorded on the day prior to admission (the 95th percentile) was associated with a 3.7% (p < 0.0001) increase in respiratory admissions and a 2.8% (p < 0.0001) increase in cardiac admissions. Increases were observed for all age groups examined. Admissions for cardiac diseases increased 2.5% for those under 65 years and 3.5% for those 65 years and older. After adjusting for ambient temperature and ozone, similar increases in respiratory admissions were observed in the period from April to September (3.2%) and in the period from October to March (2.8%). A 3.2% increase was observed for cardiac admissions in the period from April to September, and a 3.4% increase was observed in the period from October to March after adjusting for ambient temperature and ozone.

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The association between daily variations in ambient concentrations of nitrogen dioxide (NO2) and mortality was examined in 12 of Canada's largest cities, using a 19-yr time-series analysis (from 1981-1999). The authors employed parametric statistical methods that are not subject to the recently discovered convergence and error estimation problems of generalized additive models. An increase in the 3-d moving average of NO2 concentrations equivalent to the population-weighted study mean of 22.4 ppb was associated with a 2.25% (t = 4.45) increase in the daily nonaccidental mortality rate and was insensitive to adjustment for ozone, sulfur dioxide, carbon monoxide, coefficient of haze, size-fractionated particulate mass, and the sulfate ion measured on an every-6th-day sampling schedule. The 3-d moving average of NO2 was sensitive to adjustment for fine particulate matter measured daily during the 1998-2000 time period.

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