Space travelers are exposed to unique forms of ionizing radiation that pose potentially serious health hazards. Prior analyses have attempted to quantify excess mortality risk for astronauts exposed to space radiation, but low statistical power has frustrated inferences. If exposure to deep space radiation were causally linked to deaths due to two particular causes, e.g., cancer and cardiovascular disease, then those cause-specific deaths would not be statistically independent. In this case, a Kaplan-Meier survival curve for a specific cause that treats deaths due to competing causes as uninformative censored events would result in biased estimates of survival probabilities. Here we look for evidence of a deleterious effect of historical exposure to space radiation by assessing whether or not there is evidence for such bias in Kaplan-Meier estimates of survival probabilities for cardiovascular disease and cancer. Evidence of such bias may implicate space radiation as a common causal link to these two disease processes. An absence of such evidence would be evidence that no such common causal link to radiation exposure during space travel exists. We found that survival estimates from the Kaplan-Meier curves were largely congruent with those of competing risk methods, suggesting that if ionizing radiation is impacting the risk of death due to cancer and cardiovascular disease, the effect is not dramatic.
Our findings mainly characterize mortality among the first cosmonauts who have flown to space from 1961 through the 1970s, which indicates the necessity of continuing research.Ushakov IB, Voronkov YI, Bukhtiyarov IV, Tikhonova GI, Gorchakova TYu, Bryleva MS. A cohort mortality study among Soviet and Russian cosmonauts, 1961-2014. Aerosp Med Hum Perform. 2017; 88(12):1060-1065.
Aim:The purpose of the study was to carry out comparative analysis of the status and trends in mortality of male and female population of working age (15-59 (54) years) in Russia and the EU-27. Materials and methods: Based on official Russian (Rosstat) data, on the global database of the World Health Organization's cause of death (The WHO Mortality Database, WHOMD) and databases The Human MortalityDatabase (HMD) of the sex-age composition of the population and the number of deaths from certain causes of death by age and sex standardized (direct method) mortality rates of working age population from selected causes of death for 1990 and 2011 in Russia and the average for the EU-27 were calculated. Results: Analysis of trends in mortality of male and female population of working age in Russia over the past two decades shows that, despite the positive changes in during last six years, in 2011, age-standardized mortality rates remained above the 1990 level for most causes of death. During the same period in the EU-27 mortality in men (15-59 years) and women (15-54 years) increased from almost all causes of death, which led to an even greater gap between Russia and developed countries on this indicator: standardized mortality rate of the male population of Russia in 1990 was higher than in the EU-27 by 2.1 times, and by 2011 the gap had increased to 3.5 times. The women in the 1990 had 1.5 times higher standardized mortality rates, and by 2011 the gap had increased to 2.7 times. Conclusion: Despite a steady decline in the mortality rates of working age population after 2005, its level in 2012 was still higher than the one of 1990 for both men and women, which led to a further increase in the gap between the age-standardized coefficients of mortality rate of working age population in Russia and the countries of European ). Faster reduction of mortality rate in the working age population will preserve Russian population and its labor potential. Key words: mortality of working age population, trends, structure of causes of death, standardized mortality rates.
Introduction. Issues of preserving the health and saving of the Russian population are important in the development of state programs. One of the main sources of population growth, as well as the preservation of the labor potential of our country, is the reduction of the death rate of the working - age population. The aim of the study was to analyze the mortality of the population in the age groups 15-59 years and 15-64 years for men and 15-54 years and 15-59 years for women in Russia in comparison with the countries of the European Union (EU-28). Materials and methods. Mortality was studied based on data from Rosstat and the WHO Mortality Database and the Human Mortality Database. Age-standardized mortality rates were calculated for Russia in 2018 and the EU-28 countries in 2017 (European standard, revised 2013). Results. Comparative analysis of the standardized mortality rates of the population 15 to 59 years and 15-64 years for men and 15-54 years of age and 15-59 years of age showed a significant gap between Russia and the EU-28. Differences in mortality among men in comparison with the EU-28 in the age group of 15-59 years was 3.1 times, and in the age group 15-64 years - by 2.8 times. In women aged 15-54 years, the excess was 2.5 times, and in those aged 15-59 years - 2.2 times. Conclusions. Thus, the analysis of modern data on the mortality of the male (aged 15-59 and 15-64 years) and female (aged 15-54 and 15-59 years) populations indicated that negative trends persist in Russia's lagging behind the European Union countries.
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