Current state of mortality of the working-age population in Russia and Europe

Gorchakova, Tatyana Yu.; Чуранова, А.Н.

doi:10.31089/1026-9428-2020-60-11-756-759

Cited by 8 publications

(1 citation statement)

References 1 publication

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“…Прямое и опосредованное через нейрогуморальные факторы воздействие вибрационной энергии приводит к нарушению структурной организации мышечных волокон миокарда [5]. Эти факты требуют патогенетически обоснованных подходов к терапии, с учетом не только вибропротективного эффекта лекарственных препаратов, но и необходимости торможения и обратного развития ремоделирования миокарда с целью снижения инвалидизации и смертности у пациентов с ВБ [6].…”

Section: Introductionunclassified

Mechanisms of vibration-induced structural myocardial remodeling

Vorobieva,

Levchenkova,

Lenskaya

et al. 2024

Rev Clin Pharm Drug Ther

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The review presents literature data analysis devoted to the study of structural changes in the heart in patients with vibration disease, identified by echocardiographic methods in the form of concentric remodeling of the left ventricle chambers and disturbance of its diastolic function, a decrease in the intensity of the heart structure work compared to healthy ones in 1.2 times (p0.05). The changes in morphometric and bioenergetic parameters of cardiomyocytes against the background of various experimental vibration modes (7 and 56 sessions with a frequency of 8 Hz) confirms the violation of the ideal relationship between the spatial configuration of the heart cavities, the ability to contract and the energy supply potential. The loss of cardiac myofibrils symbolizes the convertion of myocardial hypertrophy to the decompensation stage and the increase in degenerative (dystrophic) signs, in particular the loss of sarcomeres of cardiomyocytes. To realize the processes of pathological structural (morphological) and energy restructuring of tissue under the influence of vibration-mediated hemodynamic and ischemic factors, it is necessary to involve in the process numerous mediators that regulate metabolism, proliferation, growth and survival of cells, such as STIM (stromal interaction molecule), SERCA (calcium ATPase of the endo(sarco)plasmic reticulum), IP3R (inositol-1,4,5-triphosphate receptor), Orai (protein that forms CRAC channels), TRPC (transient receptor potential canonical), etc. As one of the most important link of structural cardiac remodeling is performed by the degradation system of the extracellular matrix, including matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), which regulate the rate of mRNA synthesis on the DNA matrix by binding to specific DNA regions that control cardiac nutrition and plasticity. A lot of analyzed facts make it possible to explain some patterns of the development of cardiac remodeling in patients with vibration disease and to determine the direction of pathogenetically based approaches to therapy, taking into account not only the vibration-protective effect of drugs, but also their ability to inhibit and regress myocardial remodeling.

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Section: Introductionunclassified

Mechanisms of vibration-induced structural myocardial remodeling

Vorobieva,

Levchenkova,

Lenskaya

et al. 2024

Rev Clin Pharm Drug Ther

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Role of bioenergetic hypoxia in the morphological transformation of the myocardium during vibration disease

Vorobieva,

Levchenkova,

Lenskaya

2024

Psychopharmacology & biological narcology

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BACKGROUND: Analysis of literature on the structural changes in the heart in patients with vibration disease using echocardiographic research methods revealed a concentric type of remodeling of the left ventricular chambers, which is associated with a high risk of cardiovascular complications, including sudden cardiac death, in people of working age. AIM: To determine the role of bioenergetic hypoxia in the development of morphological transformation of the myocardium to substantiate the efficacy of pharmacotherapy for vibration disease. MATERIALS AND METHODS: The energy production activity of cellular systems of heart tissue in vitro was analyzed by the polarographic method using a closed galvanic-type oxygen sensor (Clark electrode). The stressful effects of vibration were confirmed by the dynamics of the morphohistological picture of changes in the myocardial tissue of the left ventricle in the apical region after standard alcohol–paraffin wiring and staining of histological preparations with hematoxylin and eosin. RESULTS: Evaluation of the morphometric and bioenergetic parameters of cardiomyocytes under various experimental vibration modes (7, 21, and 56 sessions with a frequency of 8 and 44 Hz) confirmed the relationship between the provision of tissue with energy potential and morphological signs of pathological structural changes in the myocardial tissue, such as hypertrophy of cardiomyocytes, development of fibrosis, restructuring of the vascular bed, and necrosis. CONCLUSION: Analysis of the relationship between energy metabolism and morphohistological transformation of heart tissue allows us to resolve the role of universal and specific mechanisms in cardiac remodeling in the presence of vibration and pathogenetically substantiate the choice of drugs that not only have a vibration-protective effect but also inhibit pathological structural changes in the myocardial tissue.

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Diseases of the Circulatory System in the Working-Age Population of the Central Federal District in 2014–2020

Shastin,

Malykh,

Gazimova

et al. 2023

Vrach

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Diseases of the circulatory system are the main cause of death in the working-age population. The study of the incidence of diseases of the circulatory system of the population of working age in the Russian Federation at the regional level is an urgent task, which is hampered by the lack of statistical information on the incidence of this age group of the population. Objective. To study regional features and dynamics of incidence rates of diseases of the circulatory system in the working-age population of the Central Federal District in 2014–2020. Materials and methods. We conducted a continuous retrospective study based on statistics on disease incidence in the population of the Russian Federation published by the Russian Ministry of Health and the Central Research Institute of Health Care Organization and Informatization. We estimated incidence and prevalence rates of diseases of the circulatory system, including ischemic heart diseases, in the working-age population in 2014–2020 and calculated their long-term averages, standard deviations (σ) and the coefficient of variation (Сv). The Shapiro-Wilk test was used to check if the continuous variables followed a normal distribution, and the Mann-Whitney test was used to assess the differences between the rates observed in the constituent entities of Russia. Results. For the first time, incidence and prevalence rates of diseases of the circulatory system, including ischemic heart diseases, were analyzed in the adult population of working age in the subjects of the Central Federal District. In most parts of the District, we observed an increase in the incidence rates and their statistically significant differences from similar all-Russian indicators for 2014–2019. Changes in the incidence during the spread of the novel coronavirus disease (COVID-19) within the District were multidirectional. Yet, in most regions of the District, we established a statistical difference between the analyzed indicators for the years 2014–2019 and 2020. Conclusion. Incidence and prevalence rates of diseases of the circulatory system, including the ischemic heart disease, in the adult population of working age in the subjects of the Central Federal District are characterized by pronounced regional features, thus prioritizing further epidemiological studies aimed at establishing their causes and risk factors.

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Current state of mortality of the working-age population in Russia and Europe

Cited by 8 publications

References 1 publication

Mechanisms of vibration-induced structural myocardial remodeling

Mechanisms of vibration-induced structural myocardial remodeling

Role of bioenergetic hypoxia in the morphological transformation of the myocardium during vibration disease

Diseases of the Circulatory System in the Working-Age Population of the Central Federal District in 2014–2020

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