Distribution of 3H-bleomycin among organs of normal mice of various ages and old mice bearing skin carcinoma or sarcoma induced by 20-methylcholanthrene was studied and the ratios of the antibacterial activity to the radioactivity were examined. Higher concentration was shown in carcinoma than in sarcoma and in the former more than 50 % of 3H-bleomycin remained in an active form exhibiting antibacterial activity. Slight or no activity was observed in sarcoma. The selective effect of bleomycin on mouse skin carcinoma induced by 20-methylcholanthrene was thus suggested to be due to the low ability of the tumor to inactivate bleomycin and probably also to the high uptake in this tumor. Differences were also observed among distributions of 3H-bleomycin in lung and skin of mice of different ages. The higher concentration of its active form was shown in lung and skin of old mice at higher rate than in those of young ones.An enzymethat releases one mole of ammoniafrom bleomycin and which inactivates bleomycin was extracted from tissues. The bleomycin inactivating activity of the enzymeprotein was significantly lower in the protein extracted from squamous cell carcinoma of mice skin induced by 20-methylcholanthrene than in that extracted from sarcoma induced by the same chemical.
We have designed silicon (Si) photovoltaic (PV) cells coupled with solar-pumped fiber lasers (SPFLs), by considering the unique illumination conditions for PV cells: (1) monochromatic (1064 nm) and normal incidence, (2) large intensity, and (3) small area. We have revealed that a multilayered bandpass filter formed on the front surface of a PV cell equipped with a diffuse reflector on the back surface sufficiently traps the illumination. This, in turn, allows us to use a thin Si wafer to eliminate the detrimental effect of the series resistance in the cell under intense illumination, along with a small lateral size that is suitable for direct connection with an SPFL. Simulated conversion efficiency of the newly designed 20 μm-thick Si PV cell with the 14-layerd bandpass filter and Lambertian back reflector is 61% under normally incident 1064 nm illumination at 1 kW/cm2, which is twice as high as that of a conventional surface-textured Si solar cell of 75 μm in thickness.
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