A streptomycete strain, P3409, which produced new basic macrolide antibiotics, deltamycins A,, A2 and A3 and carbomycin A (deltamycin A4) was considered to be a new subspecies for which the name Streptomyces halstedii subsp. deltae was proposed. Deltamycins A,, A2, A3 and A4 which were active against Gram-positive bacteria were produced in organic complex media. In the course of a screening program for antibiotics, a streptomycete strain P3409 was found to produce a complex of antibiotics which was collectively named deltamycin. The complex consisted of four components designated deltamycins At, A2, As and A,. From their physicochemical properties, it was found that deltamycins A,, A2 and As were new basic macrolide antibiotics while deltamycin A4 was identical with carbomycin A1,2,. In this paper, the taxonomy of the producing strain and fermentation studies of deltamycin production are reported together with the antimicrobial activity of the different components.
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