Objective: To investigate the hepatoprotective activity of alcoholic (ALLT) and aqueous (AQLT) extracts of leaves of Tylophora indica (asclepiadaceae) against ethanol-induced hepatotoxicity. Materials and Methods: Leaf powder of Tylophora indica was successively extracted with alcohol and water. Preliminary phytochemical tests were done and the LD Departments of Pharmacology for both extracts determined. The hepatoprotective activity of the ALLT and AQLT were and *Pharmaceutical Chemistry, assessed in ethanol-induced hepatotoxic rats. V. L. College of Pharmacy, Results: The ALLT showed presence of alkaloids, carbohydrates, steroids, saponins and Raichur, India triterpenes, while alkaloids, carbohydrates and saponins were present with AQLT. The ALLT did not produce any mortality even at 5000 mg/kg while LD
Ayurveda an ancient Indian system of medicine claims to have remedy for disorders like jaundice and liver cirrhosis, which is inadequate with present allopathy. The present study was conducted to find out the hepatoprotective activity of ethanolic extracts of Baccaurea ramiflora and Microcos paniculata against alcohol and paracetamol induced liver damage in rats. Hepatotoxicity was induced by alcohol and paracetamol and the biochemical parameters such as serum glutamic oxaloacetic transaminase (sGOT), serum glutamic pyruvic transaminase (sGPT), and serum alkaline phosphatase (sALP), serum bilirubin (SB) and histopathological changes in liver were studied along with silymarin as standard hepatoprotective agents. The phytochemical investigation of the extracts showed presence of alkaloids, glycosides, tannins, saponins, proteins and flavonoids. Ethyl alcohol (1.5ml/kg) and Paracetamol (750mg/kg) has enhanced the SGPT, SGOT, ALP and billirubin level reduced. Treatment with ethanolic extracts of Baccaurea ramiflora and Microcos paniculata leaves (100mg/kg and 200mg/kg) has brought back the altered level of biochemical markers to the near normal levels almost comparable to the silymarin. The hepatoprotective activity was confirmed by histopathological examination of the liver tissue of control and treated animals. From the results it can be concluded that Baccaurea ramiflora and Microcos paniculata possesses hepatoprotective effect against alcohol and paracetamol-induced liver damage in rats.
Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.
<p>The objective of present study was to evaluate preliminary phytoconstitutents and <em>invitro</em> antioxidant potential of <em>Pentatropis nivalis </em>(Asclepiadaceae). During the preliminary phytochemical analysis, methanolic and aqueous extracts of aerial part of <em>Pentatropis nivalis</em> was screened for the presence of phenolic, saponins, flavonoids, alkaloids, tannins and phytosterols. TLC of extracts were performed by using various solvent systems. Phytochemicals screening and TLC spots of MEPN and AEPN showed the presence of glycoside, steroids, terpenoids, phenolic, saponins, Methanolic extract showed better qualitative tests for presence of secondary metabolites than aqueous extract.The in-vitro antioxidant potential of extracts were evaluated by DPPH and FRAP, and both methods showed that the plant possesses good antioxidant activity.</p>
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