Hepatoprotective Activity of Ethanolic Extract of Baccaurea Ramiflora and Microcos Paniculata Against Alcohol and Paracetamol Induced Hepatotoxicity in Albino Rats

Saha, Suvendu; Gouda, T. Shivraj; Srinivas, Siddani

doi:10.7897/2230-8407.0811234

Cited by 2 publications

(2 citation statements)

References 16 publications

(15 reference statements)

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“…According to the protocol, the death >1 animal in each group was reported as a toxic dose. Finally, non‐lethal doses were defined and used in the experiment (Saha et al., 2017).…”

Section: Methodsmentioning

confidence: 99%

Aubergine stem restores reproductive damages following diabetes mellitus induction in male mice

Rostamzadeh,

Shokri‐Asl,

Torghabeh

et al. 2023

Food Science & Nutrition

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Diabetes mellitus unbalances cellular antioxidant levels. This phenomenon can potentially lead to cellular damage and apoptosis in the male reproductive system. Besides, herbal‐based antioxidants can prevent these detrimental changes. Thus, we assessed the probable role of Aubergine stems with antioxidant and anti‐hyperlipidemic characteristics on reproductive damage following diabetes mellitus induction. Forty male NMRI mice were categorized into groups of control and treatments. Diabetes was induced by a single dose of streptozotocin (60 mg/kg), and the extract was administered at various doses (100, 300, and 500 mg/kg) daily for 4 weeks. Antioxidative features of the extract were approved by phytochemical assays and ferric‐reducing ability of plasma. Side‐effects of diabetes were also assessed by the malondialdehyde (MDA) and Griess techniques. Sperm parameters, LH, FSH, and testosterone levels, the TUNEL assay, histopathologic alteration, and apoptotic genes (p53, caspase‐3, Bcl‐2) were evaluated. Results showed that diabetes increased oxidation levels and the extract accelerated total antioxidant capacity status. Sperm parameters and hormone levels were restored following extract administration in diabetic animals. Also, the apoptosis rate decreased following extract administration in diabetic animals. We concluded that diabetes can elevate the levels of oxidation and suppress the antioxidant power. These pathologic changes were restored by Aubergine stem, leading to decreased levels of apoptosis and normal serum levels of testosterone, LH, and FSH.

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“…According to the protocol, the death >1 animal in each group was reported as a toxic dose. Finally, non‐lethal doses were defined and used in the experiment (Saha et al., 2017).…”

Section: Methodsmentioning

confidence: 99%

Aubergine stem restores reproductive damages following diabetes mellitus induction in male mice

Rostamzadeh,

Shokri‐Asl,

Torghabeh

et al. 2023

Food Science & Nutrition

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show abstract

“…Treatment with ethanolic extracts of B. ramiflora leaves (100mg/kg and 200mg/kg) can alter the level of biochemical parameters to the near normal levels almost comparable to the silymarin. So that it can be concluded that B. ramiflora possess hepatoprotective effect against alcohol and paracetamol-induced liver damage in rats [76].…”

Section: Hepatoprotective Activitymentioning

confidence: 96%

Traditional and Pharmacological Reports of The Genus Baccaurea. A Review

Chowdhury¹,

Charu²,

Fatema³

et al. 2021

AJBSR

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Baccaurea is a genus of flowering plant belongs to the family Phyllanthaceae categorically large genus with members of up to 100 species and few of which have been recognized as popular healing plants in South-East Asia. (B. ramiflora), (B. angulata), (B. courtallensis), (B. macrophylla), (B. macrocarpa), (B. lanceolata), (B. racemosa) and (B. motleyana) are underutilized medicinal plants of the genus Baccaurea. The literature review revealed that Baccaurea species have been used traditionally in South-East Asian countries to treat various diseases. Baccaurea species have been believed to possess significant medicinal values like analgesic, anthelmintic, antioxidant, anti-diarrheal, antiatherosclerotic, anticancer, antidiabetic, neuropharmacological, thrombocytic, antimicrobial, etc. activities. Few species of the Baccaurea genus have demonstrated significant exposure to phytochemicals such as alkaloids, flavonoids, anthocyanins, carotenoids, tannins, phytosterols, saponins, phenolic compounds, steroids, rosmarinic acids, etc. Several bioactive constituents including 6′-O-vanilloylpicraquassioside D, 4′-O-(6-O-vanilloyl)-β-D-glucopyranosyl tachioside D, Icariside B5, picrotoximaesin, β-sitosterol, Sapidolide A, Daucosterol, methyl 2-hydroxy-3-methylbutanoate, quercetin, decanoic acid, etc. were also isolated and described from various species of Baccaurea. The purpose of this review is to evaluate the published article which is based on the medicinal values of different species of Baccaurea genus, provide updated information and knowledge on the ethnomedicinal, pharmacological and phytochemical properties and further phytochemical assessment opens a new prevalence, effectiveness in protection and clinical research.

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Hepatoprotective Activity of Ethanolic Extract of Baccaurea Ramiflora and Microcos Paniculata Against Alcohol and Paracetamol Induced Hepatotoxicity in Albino Rats

Cited by 2 publications

References 16 publications

Aubergine stem restores reproductive damages following diabetes mellitus induction in male mice

Aubergine stem restores reproductive damages following diabetes mellitus induction in male mice

Traditional and Pharmacological Reports of The Genus Baccaurea. A Review

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