Hepatoprotective and Antioxidant Activity of Ethanol Extracts of <I>Dipterocarpus turbinatus</I> (Dipterocarpaceae) from Tripura

Abstract

Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

Hepatoprotective activity of the ethanolic extracts of Dipterocarpus turbinatus leaves in Paracetamol induced hepatotoxicity in rats

“…A cytotoxic compound Diptindonein E was isolated from the acetone extracts of the bark of (Muhtadi et al, 2009). Ethanolic extract of D. hasseltii the bark showed antioxidant and hepatoprotective D.turbinatus activity (Biswas et al, 2016). Our present study was carried out for the determination of antioxidant and hepatoprotective activity of the ethanolic extract of leaves D.turbinatus .…”