The chemical composition of the volatile extract (yield ≈ 0.13%, v/w) from the bark of Quercus leucotrichophora (Fagaceae) was analysed for the first time by GC-MS. Twenty-three constituents, amounting to 93.0% of the total detected contents of the volatile extract, were identified. The volatile extract contained approximately 86.36% monoterpenoids, 6.53% sesquiterpenoids and 0.11% aliphatic aldehydes. 1,8-Cineol (40.359%) followed by γ-terpinene (16.369%) were the major monoterpene constituents of the volatile extract. The residue of volatile extract (0.00025-250 µg mL(-1)) exhibited a potent antimicrobial activity against Streptococcus pyogenes ATCC 19615. This study concludes that residues of the volatile extract of Q. leucotrichophora could serve as an important bioresource for the extraction and isolation of monoterpenoids exhibiting antimicrobial activity, and thus has good potential for use in the pharmaceutical industry.
Objective: The study is designed for the evaluation of in vivo hepatoprotective and in vitro antioxidant activity of ethanol extracts from the bark of Shorea robusta (EESR) (Dipterocarpaceae) by carbon tetra chloride (CCl 4 ) induced hepatotoxicity in rats.Methods: EESR was evaluated for hepatoprotective activity in rats by inducing liver damage by CCl 4 . The antioxidant activity of EESR was assayed by various in vitro antioxidant methods and activities were compared to standard ascorbic acid.
Results:Ethanol extracts at an oral dose 200 mg/kg and 400 mg/kg exhibited a significant (*p<0.005) protective effects by lowering the level of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, alkaline phosphatase, serum bilirubin, total cholesterol, and increasing the level of total proteins as compared to silymarin (50 mg/kg) used as positive control. The extracts exhibit significant antioxidant activity in various in vitro antioxidant models.
Conclusion:From these studies, we are concluding that, the EESR have potent hepatoprotective effects and have antioxidant properties, hence can be used as a natural product against liver damage.
Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.
Objective: Dipterocarpus turbinatus is a large woody plant widely grown in Northeastern state, Tripura. Ethanol extract of leaves was evaluated for its antioxidant and hepatoprotective activity.
D. turbinatusMaterials and Methods: The preliminary phytochemical study was carried out to find out the presence of various phytoconstituents in different extracts obtained by cold maceration. Antioxidant activity was done by Nitric oxide scavenging and DPPH* scavenging. Paracetamol (3gm/kg) was used to induce hepatotoxicity in rats and 200mg/kg & 400mg/kg of ethanol extract of leaves of (EEDT) was used for the study, while silymarin (50mg/kg) was used as a standard. D. turbinatus Blood was collected by retro-orbital puncture and various biochemical parameters were determined by photometric analysis.: Ethanolic extract showed different bioactive constituents like flavonoid, phenolic, alkaloid, tannin.
ResultsPlant extract was exhibited antioxidant properties. Tested extracts showed a significant reduction in the elevated level of various biochemical parameters like SGOT, SGPT, ALP, total bilirubin & increase the level of protein level with the dose-dependent manner. Histopathological studies of the liver of the tested animal showed there is an improvement in the architecture of the hepatic cell with plant extract treatments.The results suggest that ethanolic extract Conclusion: of leaves in different dose shows significant hepatoprotective activity against paracetamol-induced D.turbinatus hepatotoxicity in rats.
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