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A product of microbiological cleavage of the sterols side chain, androsta-1,4-diene-3,17-dione, is toxic for bacteria, in particular, actinobacteria of the genera Mycobacterium and Arthrobacter. Sterols were transformed into androsta-1,4-diene-3,17-dione by culturing the M. neoaurum VKPM An-1656 strain in a high yield, provided that a sorbent was used for elimination of contact between the bacterial cells and the product. Unlike the cholesterol side chain, the more branched chains of phytosterols were cleaved in the presence of M. neoaurum at a high rate only under turbulent stirring of the culture medium, which intensified the formation of hydrocarbonate ion from NaNI3 in situ.

The monograph consists of reviews prepared by specialists having scientific publications, theoretical knowledge and practical experience in research of immobilized cells of different microorganisms, plants and animals, which they conducted for the last decade. The basis of the reviews is composed by the scientific results of the authors and relevant data on the discussed topics, presented in the modern world literature. The monograph collected information about the characteristics of immobilized cells, various approaches used to their regulation, the possible long-term functioning and storage of such cells. It performs the prospects for application of immobilized cells in biomedicine, biodetection systems, synthetic processes of biologically active substances and in overcoming environmental problems. The monograph is intended for specialists in the field of biotechnology, heterogeneous catalysis, green chemistry, biochemistry, biophysics, ecology, cytology, biomedicine as well as for teachers and students of natural science and technological faculties of higher educational institutions, for anyone interested in new results of research on the properties of various cells and applied aspects of their possible use.

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