A search for microscopic fungi with directed hydroxylase activity for the synthesis of steroid drugs

Karpova, N. V.; Andryushina, V. A.; Stytsenko, T. S.; Дружинина, А. В.; Feofanova, T. D.; Кураков, А. В.

doi:10.1134/s000368381603008x

Cited by 9 publications

(12 citation statements)

References 16 publications

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“…In the pharmaceutical industry, ergosterol is a precursor of vitamin D2 and steroid hormone drugs [5]. For example, cortisone and progesterone can be produced from ergosterol [6,7]. Steroid drugs have important physiological activities and are the second most used clinical drugs after antibiotics; converted vitamin D2 can also be used as a feed additive to increase the oviposition and hatching rate of poultry [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…For example, cortisone and progesterone can be produced from ergosterol [6,7]. Steroid drugs have important physiological activities and are the second most used clinical drugs after antibiotics; converted vitamin D2 can also be used as a feed additive to increase the oviposition and hatching rate of poultry [6,7]. In recent years, new functions of ergosterol have been found.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae

et al. 2017

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Ergosterol, an important component of the fungal cell membrane, is not only essential for fungal growth and development but also very important for adaptation to stress in fungi. Ergosterol is also a direct precursor for steroid drugs. The biosynthesis of ergosterol can be divided into three modules: mevalonate, farnesyl pyrophosphate (farnesyl-PP) and ergosterol biosynthesis. The regulation of ergosterol content is mainly achieved by feedback regulation of ergosterol synthase activity through transcription, translation and posttranslational modification. The synthesis of HMG-CoA, catalyzed by HMGR, is a major metabolic check point in ergosterol biosynthesis. Excessive sterols can be subsequently stored in lipid droplets or secreted into the extracellular milieu by esterification or acetylation to avoid toxic effects. As sterols are insoluble, the intracellular transport of ergosterol in cells requires transporters. In recent years, great progress has been made in understanding ergosterol biosynthesis and its regulation in . However, few reviews have focused on these studies, especially the regulation of biosynthesis and intracellular transport. Therefore, this review summarizes recent research progress on the physiological functions, biosynthesis, regulation of biosynthesis and intracellular transportation of ergosterol in. .

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae

et al. 2017

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“…The collections created within the framework of the Project became a unique database for studies of practically important microorganisms. Strains–producers of broad-spectrum antibiotics from the peptaibol family [182], the anticancer metabolite Brefeldin-A, as well as potential steroid producers, have been identified [183]. The study of phytopathogenic fungi in both natural habitats, which are reservoirs of phytopathogens, and in agrocenoses is of great interest and practical importance [184].…”

Section: Microorganisms and Fungimentioning

confidence: 99%

“Noah’s Ark” Project: Interim Results and Outlook for Classic Collection Development

et al. 2018

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ANIMALSThe purpose of a biobank is to accumulate collections that adequately reflect the multidimensional structure of biodiversity (BD), making it possible to explore its various manifestations. An analysis of the scientific status of zoological collections was carried out [1], and it was shown that the collections perform the function of a research sample in BD studies. Their main characteristics are their representativeness, which is further detailed by their informational value, reliability, systemic character, scope, structure, etc.The studies in the "Animals" section are aimed at analyzing key aspects of BD on the basis of an integrated approach combining phylogenomic and phylo-ABSTRACT The "Noah's Ark" project, afoot at M.V. Lomonosov Moscow State University since 2015 and aimed at studying biodiversity, is the largest ongoing Russian project in life sciences. During its implementation, several hundred new species have been described; a comprehensive genetic and biochemical characterization of these species, as well as that of the pre-existing specimens in Moscow University's collections, has been performed. A consolidated IT system intended to house the knowledge generated by the project has been developed. Here, we summarize the investigations around the Moscow University classical biocollections which have taken place within the framework of the project and discuss future promise and the outlook for these collections.

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“…The collections created within the framework of the Project became a unique database for studies of practically important microorganisms. Strains-producers of broad-spectrum antibiotics from the peptaibol family [182], the anticancer metabolite Brefeldin-A, as well as potential steroid producers, have been identified [183]. The study of phytopathogenic fungi in both natural habitats, which are reservoirs of phytopathogens, and REVIEWS in agrocenoses is of great interest and practical importance [184].…”

Section: Microorganisms and Fungimentioning

confidence: 99%

“Noah’s Ark” Project: Interim Results and Outlook for Classic Collection Development

Kalyakin¹,

Seregin²,

Solovchenko³

et al. 2018

Acta Naturae

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The "Noah's Ark" project, afoot at M.V. Lomonosov Moscow State University since 2015 and aimed at studying biodiversity, is the largest ongoing Russian project in life sciences. During its implementation, several hundred new species have been described; a comprehensive genetic and biochemical characterization of these species, as well as that of the pre-existing specimens in Moscow University's collections, has been performed. A consolidated IT system intended to house the knowledge generated by the project has been developed. Here, we summarize the investigations around the Moscow University classical biocollections which have taken place within the framework of the project and discuss future promise and the outlook for these collections.

show abstract

A search for microscopic fungi with directed hydroxylase activity for the synthesis of steroid drugs

Cited by 9 publications

References 16 publications

Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae

Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae

“Noah’s Ark” Project: Interim Results and Outlook for Classic Collection Development

“Noah’s Ark” Project: Interim Results and Outlook for Classic Collection Development

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