Plasmonic biosensors, particularly arrays of nanoholes on thin gold films, have been widely explored in recent years as possible platforms for fast medical diagnostic. In this work, we present a screening method for leukemia cancer markers that uses a plasmonic biosensor based on nanohole arrays fabricated on plastic substrates. The low-cost, scalable, and reproducible nanohole array structures were fabricated by UV nanoimprinting technique. The relative concentration of human immunoglobulin kappa and lambda light chains in blood serum was employed as a screening method. The kappa/lambda concentration ratio was used to determine an unbalance in the immunoglobulin production due to leukemia. The platform was tested using serum samples from patients with known leukemia diagnoses. The results indicated that this inexpensive and flexible plasmonic platform is a promising tool for routine screening in clinical settings.

In this work a nano-enabled gravimetric chemical sensor prototype based on single-stranded DNA (ss-DNA) decorated single-walled carbon nanotubes (SWNT) as nano-functionalization layer for Aluminun Nitride (AIN) contour-mode resonant-MEMS gravimetric sensors has been demonstrated. Two resonators fabricated on the same silicon chip and operating at different resonance frequencies, 287 and 450 MHz, were functionalized with this novel bio-coating layer to experimentally prove the capability of two distinct single strands of DNA bound to SWNT to enhance differently the adsorption of volatile organic compounds such as dinitroluene (DNT, simulant for explosive vapor) and dymethyl-methylphosphonate (DMMP, a simulant for nerve agent sarin). The introduction of this bio-coating layer addresses the major drawbacks of recovery time (50% recovery in less than 29 seconds has been achieved) and lack of selectivity associated with gas sensor based on polymers and pristine carbon nanotube functionalization layers. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of the University of Pennsylvania's products or services. Internal or personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution must be obtained from the IEEE by writing to pubs-permissions@ieee.org. By choosing to view this document, you agree to all provisions of the copyright laws protecting it. The introduction of this bio-coating layer addresses the major drawbacks of recovery time (5000 recovery in less than 29 seconds has been achieved) and lack of selectivity associated with gas sensor based on polymers and pristine carbon nanotube functionalization layers. Author(s)Chiara