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The aim of this report is to provide a picture about Hungarians' attitudes and behaviors 1 month after the first COVID-19 case was confirmed in Hungary. Based on survey data from 1,552 adults that were collected in mid-April 2020, it appears that Hungarians agree with and follow the preventive measures of the government. There are, however, differences between 3 age groups (i.e., 18 -30, 31-59, and 60ϩ years), people with different perceived health status (i.e., good, average, and below average), and the genders. In Hungary young people, those with perceived average or below-average health, and women report the most stress during the early phase of the COVID-19 period.

The COVID-19 pandemic affects the whole world. Spain is 5th in the world and 3rd in Europe with the largest number of diagnosed cases. Spanish citizens' attitudes are important in controlling the pandemic. This research assessed attitudes of Spaniards toward COVID-19 in two studies. One (n = 64) was conducted in a shopping centre in Madrid and another (n = 640) online. The results of both studies suggest that women in Spain have a 'more responsible' attitude toward the COVID-19 than men. Young adults (18-25 years) scored lower on compliance with safety measures and perceived need to stay home than older adults. In Study 1, level of compliance, knowing someone at risk, and knowing someone infected predicted 31.2% of the variance in the perceived need to stay home. In Study 2, personal concern, level of compliance, keeping distance from others, and perceived social alarm predicted 28.5% of the variance in perceived need to stay home. Regardless of age and/or gender, Spanish people's personal concern about COVID-19 was less than their perceived social alarm about it. These results might help policy makers in considering public attitudes which could play an important role in controlling the current, and possibly a second, wave of COVID-19.

The COVID-1 pandemic affects the whole world. Spain is 3rd in the world and 2nd in Europe with largest number of diagnosed cases. Spanish citizens’ attitudes are important in controlling the pandemic. This research assessed key attitudes of the Spanish people toward COVID-19. One study (n =64) was conducted in a shopping center in Madrid and another (n= 640) online. The results of both studies suggest that women in Spain have a ‘more responsible’ attitude toward the COVID-19 than men. Young adults (18-25 years) appear to perceive less threatening the epidemic than older adults. Spanish people’s personal concern about COVID-19 is less than their perceived social alarm about it. Compliance is the strongest predictor of the approval to stay at home, which is the highest rated preventive measure by the Spanish people. These results might help policy makers in targeting public attitudes which could play an important role in the exponentially rising cases of COVID-19.

Background Tacrolimus (Tac) and Cyclosporine A (CyA) calcineurin inhibitors (CNIs) are 2 effective immunosuppressants which are essential to prevent allograft rejection. Calcineurin inhibitors are known to be nephrotoxic. However, the precise mechanism of nephrotoxicity is not fully understood. In this study, we investigated the in vivo effects of CNIs on the local renal renin-angiotensin system in the collecting duct (CD). Methods Three-week-old mice were treated with either vehicle, CyA (2 mg/kg per day), Tac (0.075 mg/kg per day), CyA + Aliskiren (25 mg/kg per day), or Tac + Aliskiren for 3 weeks. Serum creatinine was measured. Renin and vascular endothelial growth factor (VEGF) contents in CD were evaluated with flow cytometry and multiphoton microscopy. The diameter of vessels was assessed with multiphoton microscopy, and the amount of renal collagen was determined by real-time polymerase chain reaction and Masson staining. Results The elevated level of serum creatinine in CNI groups was abolished by Aliskiren. Flow cytometric analysis found elevated renin content in principal cells, which was prevented by Aliskiren. This result was further confirmed with multiphoton microscopy. The VEGF content in CD correlated with reduced capillary diameter and with the formation of fibrotic islands. Conclusions Calcineurin inhibitors induce production of renin in the CD that may contribute to decreased renal blood flow. In turn, CD responds with increased VEGF production, resulting in disproportional vessel growth, further worsening the local hypoxia and striped fibrosis surrounding the CDs. Aliskiren, a direct renin inhibitor blocks these effects and improves CNI-induced nephropathy by decreasing renin production in the CDs. Our data suggest that Aliskiren may be used for the prevention of CNI nephrotoxicity.

Various levels of lockdown due to COVID-19 limit people’s habitual physical activity. Individuals addicted to exercise, health-oriented, and team-exercisers could be the most affected. We examined the COVID-19-related changes in exercise volume in 1079 exercisers from eight Spanish-speaking nations based on exercise addiction categories, primary reasons for exercise, and forms of exercise. The COVID-19-related decrease in exercise volume was 49.24% in the sample. The proportion of the risk of exercise addiction was 15.2%. Most (81.7%) of the participants exercised for a health-related reason. These exercisers reported lesser decrease in their exercise volume than those exercising for social reasons. The risk of exercise addiction was inversely related to changes in exercise volume, but after controlling for passion and perfectionism the relationship vanished. The reported effect of COVID-19 on training did not differ between the exercise addiction groups. The findings also confirm that exercise addiction research should control for passion and perfectionism.

The findings illustrate that, independently of the physical effort, Bikram yoga is a new mild form of exercise that reduces negative-affect and state-anxiety, and the reduction is directly related to the perceived stress. Therefore, Bikram yoga appears to be beneficial for all practitioners, but even more so for the individuals who experience substantial stress in the daily life.