Routine interval appendicectomy after initial successful conservative treatment is not justified and should be abandoned. At present, there is no consensus for the management of appendiceal mass. There is, therefore, a need to develop a protocol for the management of this common problem.

Background Adipose tissue is not only a very important source of filler but also the body’s greatest source of regenerative cells. Objectives In this study, adipose tissue was cut to the desired dimensions using ultra-sharp blade systems to avoid excessive blunt pressure and applied to various anatomical areas—a procedure known as Adjustable Regenerative Adipose-tissue Transfer (ARAT). MEchanical Stromal-cell Transfer (MEST) of regenerative cells from fat tissue was also examined. Methods ARAT, MEST, or a combination of these were applied in the facial area of a total of 24 patients who were followed for at least 24 months. The integrity of the fat tissue cut with different diameter blades is shown histopathologically. The number and viability of the stromal cells obtained were evaluated and secretome analyses were performed. Patient and surgeon satisfaction were assessed with a visual analogue scale. Results With the ARAT technique, the desired size fat grafts were obtained between 4,000- and 200-micron diameters and applied at varying depths to different aesthetic units of the face, and a guide was developed. In MEST, stromal cells were obtained from 100 mL of condensed fat using different indication-based protocols (IPs) with 93% mean viability and cell counts of 28.66–88.88 × 106. Conclusions There are two main complications in fat grafting: visibility in thin skin and a low retention rate. The ARAT technique can be used to prevent these two complications. MEST, on the other hand, obtains a high rate of fat and viable stromal cells without applying excessive blunt pressure.

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For the first time, we demonstrated that both cholinergic and non-adrenergic non-cholinergic mechanisms are responsible for the altered motility in corrosive esophageal injury. Our results suggest that PRP treatment may be helpful in regulating the esophageal motility and decreasing altered contractions in corrosive burns. This effect may also contribute to the reduction of stricture formation, especially by reducing inappropriate contractions of the esophageal wall during the post-burn healing phase.

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