The effect of platelet-rich plasma on motility changes in experimental caustic esophageal burn

Öztan, Mustafa Onur; Öztan, Şule; Düzenli, Neslihan; Olukman, Murat; Köylüoğlu, Gökhan

doi:10.1007/s10388-018-0613-0

Cited by 5 publications

(3 citation statements)

References 25 publications

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“…As in these studies, many substances have been investigated in terms of their effects on the healing of corrosive esophagitis. Examples of these are methylene blue, polaprezinc, garlic (Allium sativum) oil, or platelet rich plasma [18][19][20][21] . The common aspect of all these substances is that they have anti-inflammatory and antioxidant effects.…”

Section: Discussionmentioning

confidence: 99%

The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

Özden

GÖMEÇ

Şahin

et al. 2022

CMJ

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Background: Corrosive esophageal burns have high morbidity and mortality. The effective treatment is controversial. In our study, we aimed to examine the effects of resveratrol (RSV) and platelet rich plasma (PRP) on healing in the corrosive esophagitis model in rats. Material and methods: A total of 24 rats were randomly divided into 4 groups each as esophagitis, control, PRP and RSV groups. No treatment was administered to the control group. The esophagitis model was induced in the esophagitis and treatment groups. The esophagitis group was not treated. PRP group was treated with PRP, RSV group was treated with RSV. Pathological and biochemical examinations were performed from distal esophagitis. Results: The highest tissue IL-1, IL-6, and TNF-α levels were observed in the esophagitis group. The lowest tissue IL-1, IL-6, and TNF-α levels were noted in the control group. The highest tissue TAS levels were observed in the control group. The lowest tissue TAS levels were noted in the esophagitis group. The other groups had significantly lower mean tissue TOS and OSI levels than the esophagitis group (P

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Section: Discussionmentioning

confidence: 99%

The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

Özden

GÖMEÇ

Şahin

et al. 2022

CMJ

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“…This effect may also contribute to the reduction of stricture formation, especially by reducing inappropriate contraction of the esophageal wall during the postburn healing phase. To prevent stricture formation, many experimental studies have been performed to evaluate the therapeutic efficacy of agents such as betaaminopropionitrile, platelet-rich plasma, sucralfate, trimetazidine, pentoxifylline, 3-amino-benzamide (3-AB) and ketotifen 3,25,26 . Also, some chemical components from a few species of mushrooms including golden needle mushroom 27 and Agaricus blazei 28 were reported to possess strong anti-inflammatory activity in burned rats, suggesting a possible candidate to be a promoting agent of the burn wound healing.…”

Section: Discussionmentioning

confidence: 99%

Cordycepin prevents the esophageal stricture formation in the alkali-burn rat model by exerting anti-inflammatory and antifibrotic effects

et al. 2021

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Purpose To investigate the efficacy of cordycepin, an adenosine analogue, on prevention of esophageal damage and stricture formation due to esophageal caustic burns in rat model comparing with prednisolone. Methods Caustic esophageal burn was introduced by 37.5% of NaOH to distal esophagus. Thirty-two Wistar albino rats were divided in four groups: sham rats undergone laparotomy, treated with 0.9% NaCl; control rats injured with NaOH without cordycepin treatment; cordycepin group injured with NaOH, treated with 20 mg/kg cordycepin; prednisolone group injured with NaOH, treated with 1 mg/kg prednisolone for 28 days. Efficacy was assessed by histopathological and immunohistochemical analysis of esophageal tissues. Results Cordycepin treatment significantly decreased inflammation, granulation tissue and fibrous tissue formation and prevented formation of esophageal strictures shown by histopathological damage score and stenosis indexes compared to control group (p < 0.01). These effects are relatively more substantial than prednisolone, probably based on attenuation of elevation of proinflammatory cytokines hypoxia-inducible factor 1-alpha (HIF-1?), tumor necrosis factor alpha (TNF-?), proliferative and fibrotic factor fibroblast growth factor 2 (FGF2) and angiogenic factor vascular endothelial growth factor A (VEGFA) (p < 0.05). Conclusions The findings suggest that cordycepin has a complex multifactorial healing process in alkali-burned tissue, more successful than prednisolone in preventing the formation of esophageal strictures and may be used as a therapeutic agent in the acute phase of esophageal alkali-burn.

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“…The radicals affected cell membranes and induced accumulation of neutrophils in the affected tissue. Oztan et al 27 report that the esophageal contractile response, which is related to esophageal smooth muscle activity, decreases after experimental caustic burns.…”

Section: Fig 5 (A) Control Group: Tnf-α Expression In Macrophages Of ...mentioning

confidence: 99%

Does Gallic Acid Have a Potential Remedial Effect in Experimental Corrosive Burn Injury to the Esophagus?

Basuguy

2023

ACC

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Corrosive agents often cause esophageal burns in acute phase, and give rise to narrowing of the esophagus in chronic phase. Corrosives may also burn soft tissues in the oral cavity and stomach. After ingestion of a corrosive substance, perforated esophagus or stomach may be seen within the first weeks 1 . The nature (acidic or alkaline) and amount of the solid or liquid substance ingested determines the type and degree of damage to the digestive system. After the corrosive agent is ingested, esophageal narrowing may arise, along with acute perforation and even death 2 . Various medical agents have been studied for the treatment of esophageal narrowing and management of the healing of esophageal burns 3 . Esophageal burns are generally caused by alkaline intake. Alkaline compounds affect esophageal tissue cell lipoprotein components. Liquefaction necrosis occurs due to severe injury in deep cell layers, such as the muscular layer 4 . The severity of injury also varies depending on the substance pH and tissue exposure time 5,6 . NaOH is often used in experimental models of esophageal burn to investigate aspects of alkaline injury 7 . It is known that free oxygen radical formation and lipid peroxide oxidation occur in esophageal burns, and these initiate tissue injury via oxidative stress. When a corrosive substance is ingested, free oxygen radical levels increase within 24 h

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The effect of platelet-rich plasma on motility changes in experimental caustic esophageal burn

Cited by 5 publications

References 25 publications

The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

The healing effect of resveratrol and platelet rich plasma in corrosive esophagitis model in rats

Cordycepin prevents the esophageal stricture formation in the alkali-burn rat model by exerting anti-inflammatory and antifibrotic effects

Does Gallic Acid Have a Potential Remedial Effect in Experimental Corrosive Burn Injury to the Esophagus?

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