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Oral drug delivery to the colon is of interest for the local treatment of colonic diseases and for the systemic delivery of drugs. Our goal is to develop coating materials that are stable in gastric and small intestinal fluids and degradable in the colon by bacterial polysaccharidases. For testing colon‐degradability an in vitro model was developed. A number of polysaccharide derivatives were synthesized and tested: almost completely ethylated or acetylated galactomannans, polyurethanes with galactomannan sections, crosslinked galactomannans and dextranesters of fatty acids. Generally, degradability decreased with increasing degree of substitution. Especially crosslinked galactomannan and dextranesters with a low degree of substitution or crosslinking, respectively, are promising materials. Using an industrial coating technique tablets were coated with crosslinked galactomannan and the enzymatically induced in vitro dissolution of a model drug was investigated.

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