Lauroyldextran and crosslinked galactomannan as coating materials for site-specific drug delivery to the colon

Hirsch, Stefan; Binder, Vera; Schehlmann, Volker; Kolter, Karl; Bauer, Kurt

doi:10.1016/s0939-6411(98)00089-7

Cited by 31 publications

(11 citation statements)

References 9 publications

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“…However, mechanical instability of the films was observed, especially at higher coating quantities, thereby suggesting their non-suitability for application in colonic carrier production. [106]…”

Section: Biopharmaceutical Applications Of Locust Bean Gummentioning

confidence: 99%

Locust bean gum: Exploring its potential for biopharmaceutical applications

2012

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Polysaccharides have been finding, in the last decades, very interesting and useful applications in the biomedical and, specifically, in the biopharmaceutical field. Locust bean gum is a polysaccharide belonging to the group of galactomannans, being extracted from the seeds of the carob tree (Ceratonia siliqua). This polymer displays a number of appealing characteristics for biopharmaceutical applications, among which its high gelling capacity should be highlighted. In this review, we describe critical aspects of locust bean gum, contributing for its role in biopharmaceutical applications. Physicochemical properties, as well as strong and effective synergies with other biomaterials are described. The potential for in vivo biodegradation is explored and the specific biopharmaceutical applications are discussed.

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Section: Biopharmaceutical Applications Of Locust Bean Gummentioning

confidence: 99%

Locust bean gum: Exploring its potential for biopharmaceutical applications

2012

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“…75 Theophylline biconcave tablets (9 mm-cores with 100 mg of theophylline and excipients) were coated with a Hüttlin Kugel coater having coatings of 4-17 mg/cm 2 . Sprayable coating formulations were obtained with 4% aqueous dispersions of crosslinked galactomannan in a 1:1 mixture of 1-propanol and water.…”

Section: Film Coatingmentioning

confidence: 99%

Pharmaceutical use of galactomannans

Silveira¹,

Bresolin²

2011

Quím. Nova

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Recebido em 5/1/10; aceito em 13/8/10; publicado na web em 26/11/10 PHARMACEUTICAL USE OF GALACTOMANNANS. The pharmaceutical use of galactomannans from different sources, commercial and noncommercial, has been extensively studied over the past decade. Galactomannans show potential in the global trend towards the use of more plant-based products for ecological motives, and their production and application do not cause pollution or disturb the ecosystem. There is a variety of galactomannan sources and various pharmaceutical forms of application, such as tablets or capsules, hydrogels and films. Besides the simple use as inert excipient this polysaccharides play role in the modification of drug release, especially in colonic environmental, as a matrix or coating material.

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“…Bauer and Kesselhut (1995) synthesized dextran fatty acid ester and showed that lauroyl dextran esters with molecular weight of approximately 250,000 and degree of substitution ranging from 0.11 to 0.3 were suitable for colon targeted drug delivery as film coatings. In vitro studies with lauroyl dextrans esters bearing theophylline were carried out and Hirsch et al (1997) showed that addition of dextranase accelerated the drug release. However, further studies negated the utility of dispersion of lauroyl dextrans as coating material as they did not exhibit ideal zero-order dissolution before and quick disintegration after enzyme addition (Hirsch et al 1999).…”

Section: Dextransmentioning

confidence: 99%

“…In vitro studies with lauroyl dextrans esters bearing theophylline were carried out and Hirsch et al (1997) showed that addition of dextranase accelerated the drug release. However, further studies negated the utility of dispersion of lauroyl dextrans as coating material as they did not exhibit ideal zero-order dissolution before and quick disintegration after enzyme addition (Hirsch et al 1999). The dextran capsules appear to be excellent candidates for colon-specific drug delivery of almost any drug molecules as the polymer composition governs the specific release pattern (Bronsted, Andersen, and Hovgaard 1998).…”

Section: Dextransmentioning

confidence: 99%

Polysaccharides for Colon Targeted Drug Delivery

2004

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Colon targeted drug delivery has the potential to deliver bioactive agents for the treatment of a variety of colonic diseases and to deliver proteins and peptides to the colon for their systemic absorption. Various strategies, currently available to target the release of drugs to colon, include formation of prodrug, coating of pH-sensitive polymers, use of colon-specific biodegradable polymers, timed released systems, osmotic systems, and pressure controlled drug delivery systems. Among the different approaches to achieve targeted drug release to the colon, the use of polymers especially biodegradable by colonic bacteria holds great promise. Polysaccharidases are bacterial enzymes that are available in sufficient quantity to be exploited in colon targeting of drugs. Based on this approach, various polysaccharides have been investigated for colon-specific drug release. These polysaccharides include pectin, guar gum, amylose, inulin, dextran, chitosan, and chondroitin sulphate. This family of natural polymers has an appeal to drug delivery as it is comprised of polymers with a large number of derivatizable groups, a wide range of molecular weights, varying chemical compositions, and, for the most part, low toxicity and biodegradability yet high stability. The most favorable property of these materials is their approval as pharmaceutical excipients.

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Lauroyldextran and crosslinked galactomannan as coating materials for site-specific drug delivery to the colon

Cited by 31 publications

References 9 publications

Locust bean gum: Exploring its potential for biopharmaceutical applications

Locust bean gum: Exploring its potential for biopharmaceutical applications

Pharmaceutical use of galactomannans

Polysaccharides for Colon Targeted Drug Delivery

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