Simplification of fused deposition modeling 3D-printing paradigm: Feasibility of 1-step direct powder printing for immediate release dosage form production

Fanous, Marina; Gold, Sarah; Muller, Silvain; Hirsch, Stefan; Ogorka, Joerg; Imanidis, Georgios

doi:10.1016/j.ijpharm.2020.119124

Cited by 80 publications

(35 citation statements)

References 26 publications

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“…A high printing temperature was not appropriate because the loaded material burned quickly before printing. PVPVA64 was added to solve this problem because the presence of PVPVA64 enabled milder printing conditions such as lower temperatures [25]. The ratios of PEO/PVPVA64 were evaluated by increasing the amount of PVPVA64, and formulations from 10% to 30% of PVPVA64 were able to print (F2-4 in Table 3).…”

Section: Optimization Of Polymeric Carrier Composition For Odf Printingmentioning

confidence: 99%

“…3D printing technologies, such as inkjet, fused deposition modeling (FDM), and selective laser sintering (SLS), are more suitable for wide applications in manufacturing pharmaceutical dosage forms [24]. Among the many technologies applicable to 3D printing, the most actively used technology in the pharmaceutical industry is material extrusion, which is described as an FDM [25][26][27]. FDM 3D printing is typically explained in two steps: (i) mixing and heating materials using HME screws to obtain filaments and (ii) subsequent manufacture of objects by melting the prepared filaments.…”

Section: Introductionmentioning

confidence: 99%

“…Hot-melt pneumatic extrusion (HMPE) for single-step 3D printing as different forms of HME was used to eliminate intermediate steps, having faster possibilities for the production of substances. Powders or pellets that are directly fed into the HMPE system can be a simplified FDM paradigm, which is tailored to the printing process, the release of the drug, and dosage form [16,25,26,28].…”

Section: Introductionmentioning

confidence: 99%

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Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

et al. 2020

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Amorphous solid dispersions (ASDs) improve the oral delivery of poorly water-soluble drugs. ASDs of olanzapine (OLZ), which have a high melting point and low solubility, are performed using a complicated process. Three-dimensional (3D) printing based on hot-melt pneumatic extrusion (HMPE) is a simplified method for producing ASDs. Unlike general 3D printing, printlet extrusion is possible without the preparation of drug-loaded filaments. By heating powder blends, direct fused deposition modeling (FDM) printing through a nozzle is possible, and this step produces ASDs of drugs. In this study, we developed orodispersible films (ODFs) loaded with OLZ as a poorly water-soluble drug. Various ratios of film-forming polymers and plasticizers were investigated to enhance the printability and optimize the printing temperature. Scanning electron microscopy (SEM) showed the surface morphology of the film for the optimization of the polymer carrier ratios. Differential scanning calorimetry (DSC) was used to evaluate thermal properties. Powder X-ray diffraction (PXRD) confirmed the physical form of the drug during printing. The 3D printed ODF formulations successfully loaded ASDs of OLZ using HMPE. Our ODFs showed fast disintegration patterns within 22 s, and rapidly dissolved and reached up to 88% dissolution within 5 min in the dissolution test. ODFs fabricated using HMPE in a single process of 3D printing increased the dissolution rates of the poorly water-soluble drug, which could be a suitable formulation for fast drug absorption. Moreover, this new technology showed prompt fabrication feasibility of various formulations and ASD formation of poorly water-soluble drugs as a single process. The immediate dissolution within a few minutes of ODFs with OLZ, an atypical antipsychotic, is preferred for drug compliance and administration convenience.

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Section: Optimization Of Polymeric Carrier Composition For Odf Printingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

et al. 2020

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“…Thus, another trend was introduced by a few research groups in which the raw materials were directly fed into the printer. Recently, research groups such as Fanous et al [ 75 ], Ong et al [ 76 ], and Goyanes et al [ 77 ] discussed this approach. However, it is critical to understand that raw material homogeneity is the most important factor in this process.…”

Section: Future Perspectivesmentioning

confidence: 99%

Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review

Shaqour

Samaro

Verleije³

et al. 2020

Pharmaceutics

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Fused filament fabrication (FFF) 3D printing technology is widely used in many fields. For almost a decade, medical researchers have been exploring the potential use of this technology for improving the healthcare sector. Advances in personalized medicine have been more achievable due to the applicability of producing drug delivery devices, which are explicitly designed based on patients’ needs. For the production of these devices, a filament—which is the feedstock for the FFF 3D printer—consists of a carrier polymer (or polymers) and a loaded active pharmaceutical ingredient (API). This systematic review of the literature investigates the most widely used approaches for producing drug-loaded filaments. It also focusses on several factors, such as the polymeric carrier and the drug, loading capacity and homogeneity, processing conditions, and the intended applications. This review concludes that the filament preparation method has a significant effect on both the drug homogeneity within the polymeric carrier and drug loading efficiency.

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“…The step that involves the filament preparation can be omitted if a 3D printer was designed to be compatible with the polymer and the drug in their original form as a raw material. Interestingly, only a few studies have used such systems [4][5][6], while the vast majority of studies have used the previously mentioned approach. There are many reasons for the limited interest in systems that do not include the filament preparation step in the process.…”

Section: Introductionmentioning

confidence: 99%

3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency

et al. 2020

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Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few researchers have explored the possibility of directly 3D printing such systems without the need for producing a filament which is usually the feedstock material for the printer. This was possible via direct feeding of a mixture consisting of the carrier polymer and the required drug. However, as this direct feeding approach shows limited homogenizing abilities, it is vital to investigate the effect of the pre-mixing step on the quality of the 3D printed products. Our study investigates the two commonly used mixing approaches—solvent casting and powder mixing. For this purpose, polycaprolactone (PCL) was used as the main polymer under investigation and gentamicin sulfate (GS) was selected as a reference. The produced systems’ efficacy was investigated for bacterial and biofilm prevention. Our data show that the solvent casting approach offers improved drug distribution within the polymeric matrix, as was observed from micro-computed topography and scanning electron microscopy visualization. Moreover, this approach shows a higher drug release rate and thus improved antibacterial efficacy. However, there were no differences among the tested approaches in terms of thermal and mechanical properties.

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Simplification of fused deposition modeling 3D-printing paradigm: Feasibility of 1-step direct powder printing for immediate release dosage form production

Cited by 80 publications

References 26 publications

Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review

3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency

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