Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

Cho, Hui-Won; Baek, Seung‐Hoon; Lee, Beom‐Jin; Jin, Hosub

doi:10.3390/pharmaceutics12080692

Cited by 58 publications

(27 citation statements)

References 55 publications

(77 reference statements)

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“…Over the last two decades, HME has been employed as a novel cost-effective pharmaceutical manufacturing technique of different oral solid-dosage forms. It has been suitably used in the preparation of immediate-release, novel taste-masked and abuse deterrence tablets formulations [28,29], chrono-modulated drug delivery systems [30], for immediate release formulation of ODF [2,3], and ODF containing poorly water soluble and highly polymorphic drugs [31][32][33]. Thus, the combination of HME and additive printing technology has been shown to offer several advantages [6,33]; first, the ability to fabricate immediate-release, modified-release, and other novel drug delivery dosage forms, second, the ease to prepare personalized oral drug delivery products, • Repaglinide bioavailability was enhanced by the new film-forming alginate derivative.…”

Section: Preparation Methods Orodispersible Dosage Formsmentioning

confidence: 99%

Applications of Alginates in the Design and Preparation of Orodispersible Dosage Forms

Khalid¹,

Selmin²

2022

Properties and Applications of Alginates

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Orodispersible dosage forms are attractive and innovative drug delivery systems that can fulfill individual patient needs, especially in children, elderly and among dysphagic patients. Indeed, they rapidly disperse in the mouth upon contact with the saliva without the need for water or munching. Examples of such dosage forms include orodispersible tablets (ODT), and orodispersible films (ODF). The ability to obtain ODF with different dimensions (sizes and thicknesses) makes them a suitable for personalized dosing of single or a fixed-dose combination of drugs in special patient populations. Several biopolymers are currently being exploited in the development of orodispersible dosage forms including alginates due to their versatility, availability, naturally occurring, and biosafety profile. This chapter provides an appraisal on the various applications of alginates in the preparations and their role on the properties of orodispersible dosage forms and highlights future perspectives of this very versatile biopolymer for these innovative drug delivery systems.

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Section: Preparation Methods Orodispersible Dosage Formsmentioning

confidence: 99%

Applications of Alginates in the Design and Preparation of Orodispersible Dosage Forms

Khalid¹,

Selmin²

2022

Properties and Applications of Alginates

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“…All of the obtained ODFs were characterized by a uniform drug content, optimal strength, and rapid disintegration time and exhibited good printability. The formulation containing PEO, PVP, and poloxamer 188 indicated the fastest dissolution time and immediate dissolution profiles [77].…”

Section: Polyethylene Oxide (Peo)mentioning

confidence: 95%

“Success Depends on Your Backbone”—About the Use of Polymers as Essential Materials Forming Orodispersible Films

2021

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Polymers constitute a group of materials having a wide-ranging impact on modern pharmaceutical technology. Polymeric components provide the foundation for the advancement of novel drug delivery platforms, inter alia orodispersible films. Orodispersible films are thin, polymeric scraps intended to dissolve quickly when put on the tongue, allowing them to be easily swallowed without the necessity of drinking water, thus eliminating the risk of choking, which is of great importance in the case of pediatric and geriatric patients. Polymers are essential excipients in designing orodispersible films, as they constitute the backbone of these drug dosage form. The type of polymer is of significant importance in obtaining the formulation of the desired quality. The polymers employed to produce orodispersible films must meet particular requirements due to their oral administration and have to provide adequate surface texture, film thickness, mechanical attributes, tensile and folding strength as well as relevant disintegration time and drug release to obtain the final product characterized by optimal pharmaceutical features. A variety of natural and synthetic polymers currently utilized in manufacturing of orodispersible films might be used alone or in a blend. The goal of the present manuscript was to present a review about polymers utilized in designing oral-dissolving films.

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“…Finally, ROKIT HEALTHCARE's DR. INVIVO system has become an immensely popular tool that was cited in more than 60 publications (see Fig. 6) in a variety of applications, such as additive manufacturing for tissue engineering and regenerative medicine, [119][120][121][122][123][124][125] drug testing, 126 and pharmaceutical [127][128][129] and biomaterials research. [130][131][132] In addition to the low-cost DR. INVIVO 4D2 series, ROKIT HEALTHCARE just released a new high-cost model in 2020, INVIVO 4D6 HEALTHCARE (Suppl.…”

Section: Regemat 3d's Bio V1 and Reg4life Founded In 2015mentioning

confidence: 99%

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

et al. 2021

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Three-dimensional (3D) bioprinting has become mainstream for precise and repeatable high-throughput fabrication of complex cell cultures and tissue constructs in drug testing and regenerative medicine, food products, dental and medical implants, biosensors, and so forth. Due to this tremendous growth in demand, an overwhelming amount of hardware manufacturers have recently flooded the market with different types of low-cost bioprinter models—a price segment that is most affordable to typical-sized laboratories. These machines range in sophistication, type of the underlying printing technology, and possible add-ons/features, which makes the selection process rather daunting (especially for a nonexpert customer). Yet, the review articles available in the literature mostly focus on the technical aspects of the printer technologies under development, as opposed to explaining the differences in what is already on the market. In contrast, this paper provides a snapshot of the fast-evolving low-cost bioprinter niche, as well as reputation profiles (relevant to delivery time, part quality, adherence to specifications, warranty, maintenance, etc.) of the companies selling these machines. Specifically, models spanning three dominant technologies—microextrusion, droplet-based/inkjet, and light-based/crosslinking—are reviewed. Additionally, representative examples of high-end competitors (including up-and-coming microfluidics-based bioprinters) are discussed to highlight their major differences and advantages relative to the low-cost models. Finally, forecasts are made based on the trends observed during this survey, as to the anticipated trickling down of the high-end technologies to the low-cost printers. Overall, this paper provides insight for guiding buyers on a limited budget toward making informed purchasing decisions in this fast-paced market.

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Orodispersible Polymer Films with the Poorly Water-Soluble Drug, Olanzapine: Hot-Melt Pneumatic Extrusion for Single-Process 3D Printing

Cited by 58 publications

References 55 publications

Applications of Alginates in the Design and Preparation of Orodispersible Dosage Forms

Applications of Alginates in the Design and Preparation of Orodispersible Dosage Forms

“Success Depends on Your Backbone”—About the Use of Polymers as Essential Materials Forming Orodispersible Films

Review of Low-Cost 3D Bioprinters: State of the Market and Observed Future Trends

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