Highlights:-Monophasic polymer PS are recommended for hydrophobic substances.-Adsorption-based PS for hydrophilic substances provide semi-quantitative data.-The development of new PS for ionic and highly hydrophilic substances is required.-PS reflect the contaminant levels to which biota is exposed in waters.-PS allow to rank areas with risk of EQS exceedance before monitoring in biota. Highlights:-Monophasic polymer PS are recommended for hydrophobic substances.-Adsorption-based PS for hydrophilic substances provide semi-quantitative data.-The development of new PS for ionic and highly hydrophilic substances is required.-PS reflect the contaminant levels to which biota is exposed in waters.-PS allow to rank areas with risk of EQS exceedance before monitoring in biota. AbstractThis paper, based on the outcome of discussions at a NORMAN Network-supported *Manuscript

This context prompted the OECD 5 and the US EPA to develop new strategies to rapidly screen and characterize the endocrine activity of chemicals and environmental contaminants, specifically for estrogen, androgen and, more recently, for thyroid and metabolism-related

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