For more reliable measurements of pharmaceuticals in the environment: Overall measurement uncertainty estimation, QA/QC implementation and metrological considerations. A case study on the Seine River

Lardy-Fontan, Sophie; Brieudes, Vincent; Lalere, Béatrice; Candido, Patrick; Couturier, Guillaume; Budzinski, Hélène; Lavison-Bompard, Gwenaëlle

doi:10.1016/j.trac.2015.12.011

Cited by 12 publications

(6 citation statements)

References 23 publications

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“…Codeine is more frequently reported in European studies than in Africa (Gros et al, 2012a;Acuña et al, 2015;Lardy-Fontan et al, 2016;Petrie et al, 2016;Brieudes et al, 2016Brieudes et al, , 2017. This is in line with the global consumption pattern of codeine reported in a country report of 2015 (The Statistics Portal, 2015).…”

Section: Analgesics and Anti-inflammatories (Aaf)supporting

confidence: 85%

“…Diazepam is another compound belonging to PTDs. It was generally detected at concentration levels below 100 ng L −1 in aquatic environments of both continents (Osorio et al, 2012;Vazquez-Roig et al, 2012;Baker and Kasprzyk-Hordern, 2013;Acuña et al, 2015;Aymerich et al, 2016;K'oreje et al, 2016;Lardy-Fontan et al, 2016;Brieudes et al, 2017Brieudes et al, , 2016Urns et al, 2017). The maximum concentration of diazepam reported in African aquatic environments was around ~7 times higher than the maximum concentration reported in European based studies (Osorio et al, 2012;K'oreje et al, 2016).…”

Section: Psychiatric Treatment Drugs (Ptds)mentioning

confidence: 96%

“…Other compound investigated in this group are venlafaxine, it is used in treating depression and anxiety. With concentrations 0.19 ng L −1 to the level of 244 ng L −1 , venlafaxine was the most frequently reported drug from the anti-depressants therapeutic group (Bagnall et al, 2012;de Jongh et al, 2012;Gros et al, 2012b;Rúa-Gómez and Püttmann, 2012;Baker and Kasprzyk-Hordern, 2013;Acuña et al, 2015;Boix et al, 2015;Aymerich et al, 2016;Lardy-Fontan et al, 2016;Paíga et al, 2016;Petrie et al, 2016;Brieudes et al, 2016Brieudes et al, , 2017Ahkola et al, 2017;Archer et al, 2017b;Urns et al, 2017). Venlafaxine has not only the highest concentration recorded but is also more frequently reported in European aquatic environments than in Africa.…”

Section: Psychiatric Treatment Drugs (Ptds)mentioning

confidence: 99%

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Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge

Fekadu

Alemayehu

Dewil

et al. 2019

Science of The Total Environment

397

170

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Section: Analgesics and Anti-inflammatories (Aaf)supporting

confidence: 85%

Section: Psychiatric Treatment Drugs (Ptds)mentioning

confidence: 96%

Section: Psychiatric Treatment Drugs (Ptds)mentioning

confidence: 99%

See 1 more Smart Citation

Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge

Fekadu

Alemayehu

Dewil

et al. 2019

Science of The Total Environment

397

170

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“…The problem of drug residues in WWTP effluents was addressed in the urban wastewater treatment directive of the EC, which has been continually updated since its release in 1991 [2]. Although WWTPs use several steps for the clean-up of wastewater, namely a pretreatment, a primary, a secondary and/or a tertiary/advanced treatment, contaminants may not be removed completely and can subsequently be found in the effluent [3][4][5][6][7][8][9][10][11][12]. This is of particular concern when the treated wastewater is reused, e.g., for irrigation in agriculture, an approach that has become common practice in many arid regions [13].…”

Section: Introductionmentioning

confidence: 99%

A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the detection of drug-related metabolites in plants

Mlynek¹,

Himmelsbach²,

Buchberger³

et al. 2020

Anal Bioanal Chem

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Investigations into the interaction of xenobiotics with plants (and in particular edible plants) have gained substantial interest, as water scarcity due to climate-change-related droughts requires the more frequent use of reclaimed wastewaters for irrigation in agriculture. Non-steroidal anti-inflammatory drugs are common contaminants found in wastewater treatment plant effluents. For this reason, the interaction of nine edible plants with diclofenac (DCF), a widely used representative of this group of drugs, was investigated. For this purpose, plants were hydroponically grown in a medium containing DCF. For the detection of unknown DCF-related metabolites formed in the plant upon uptake of the parent drug‚ a new workflow based on the use of HPLC coupled to drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry (DTIM QTOF-MS) was developed. Thereby‚ for chromatographic peaks eluting from the HPLC, drift times were recorded, and analytes were subsequently fragmented in the DTIM QTOF-MS to provide significant fragments. All information available (retention times, drift times, fragment spectra, accurate mass) was finally combined‚ allowing the suggestion of molecular formulas for 30 DCF-related metabolites formed in the plant, whereby 23 of them were not yet known from the literature.

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“…Standards and guidelines have been published for the in situ determination of river water parameters or for the collection and preservation of samples that can be analyzed in the laboratory. − Some authors also studied the impact of river composition heterogeneity in the characterization of a sampling point. − However, when trends of river water composition need to be monitored, it is necessary to characterize a large river area because it is more robust to river’s heterogeneity and representative of its status. This area would be characterized by the parameter value that would be obtained after mixing and analyzing the water of the river area that is equivalent to the mean of the parameter values determined in the area.…”

mentioning

confidence: 99%

Optimization of River Sampling: Application to Nutrients Distribution in Tagus River Estuary

2019

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The assessment of river water pollution trends is affected by the seasonal variation of river conditions, the variability of pollution sources, the heterogeneity of pollutants distribution, the representativeness/uncertainty of sampling, and the uncertainty of sample analysis. This work presents a methodology to model the uncertainty of river water sampling based on available information about the spatial distribution of the studied parameter in the river. The uncertainty from “single sampling” (SS) or by production of a composite sample by mixing m subsamples collected randomly (RS) or in a line that crosses the sampling circle (LS) was studied. This methodology was applied to the determination of nutrients (NO x , NO2, PO4, and SiO2) in an area of the Tagus River estuary with a range of about 350 m. This methodology can be applied to the determination of the mean value of other parameters in other river areas requiring a previous study of system heterogeneity. The spatial distribution of nutrients in the studied river area was characterized from the analysis of 10 samples collected at known geographical coordinates. The system heterogeneity was described by a three-dimensional (x, y, z) surface with x and y variables for samples positions and z variable representing the measured nutrient levels. The randomization of this surface for the uncertainty of coordinates and repeatability of nutrient concentration measurement, using Monte Carlo simulations, allowed estimation of the uncertainty of the three sampling strategies: SS, RS, and LS. The uncertainty from RS and LS is equivalent and significantly smaller than that from SS when at least three subsamples are mixed in the composite sample. The sampling relative standard uncertainty ranged from 0.31% to 4.4%, producing nutrient concentration estimates in the river area with a relative expanded uncertainty from 5.9% to 10% with approximately 95% confidence level (coverage factor of 2). The used spreadsheet is available as Supporting Information.

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For more reliable measurements of pharmaceuticals in the environment: Overall measurement uncertainty estimation, QA/QC implementation and metrological considerations. A case study on the Seine River

Cited by 12 publications

References 23 publications

Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge

Pharmaceuticals in freshwater aquatic environments: A comparison of the African and European challenge

A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the detection of drug-related metabolites in plants

Optimization of River Sampling: Application to Nutrients Distribution in Tagus River Estuary

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