An investigation of the constitutional adaptive gelation process of chitosan/cinnamaldehyde (C/Cy) dynagels is reported. These gels generate timely variant macroscopic organization across extended scales. In the first stage, imine-bond formation takes place "in-water" and generates low-ordered hydrogels. The progressive formation of imine bonds further induces "out-of-water" increased reactivity within interdigitated hydrophobic self-assembled layers of Cy, with a protecting environmental effect against hydrolysis and that leads to the stabilization of the imine bonds. The hydrophobic swelling due to Cy layers at the interfaces reaches a critical step when lamellar self-organized hybrids are generated (24 hours). This induces an important restructuration of the hydrogels on the micrometric scale, thus resulting in the formation of highly ordered microporous xerogel morphologies of high potential interest for chemical separations, drug delivery, and sensors.
Oral rehabilitation by dental implants is a routine treatment in the common dental practice, and volume reconstruction in cases of advanced alveolar ridge atrophy using bone autografts has become a frequently used therapeutic procedure. The study presents a histological evaluation of autogenous mandibular bone grafts integration in surgically created maxillary bone defects. Seven domestic adult dogs, Canis Familiaris were used in the study. Work methodology was established through maxillary and mandibular morphometry, the donor region being the posterior mandibular body, and the recipient region being the lateral body of the maxilla. In the experimental study, we simulated two bilateral maxillary bone defects, which were augmented with mandibular corticocancellous bone grafts. Biological samples containing the target areas were collected 90-100 days after grafting and the subsequent preparation method of the samples for histological analysis was the standard one.The histological results showed the successful integration and the beneficial effect of corticocancellous autogenous mandibular bone grafts applied in maxillary sites.
Alveolar ridge augmentation with autogenous bone grafts is a frequent procedure used in Implant Dentistry. This paper presents an immunohistochemical assessment of the integration of mandibular autografts, applied in maxillary bone defects. Seven adult dogs were used in the study. The work methodology was established through maxillary and mandibular morphometry. The posterior mandibular body was considered the donor region and the lateral region of the maxilla the recipient area. Bilateral maxillary bone defects were performed on the predetermined receiving sites, which were later augmented with mandibular grafts. Fragments of hard tissue from the grafted sites were harvested 90-100 days after the surgical interventions and immunohistochemically evaluated. The immunohistochemical study proved the existence of bone regeneration in the case of mandibular corticocancellous autografts applied at the maxillary level, being an efficient procedure for assessing their integration.
This research aimed to develop an experimental animal model for the evaluation of the posterior maxillary alveolar bone and further selection of the design for a dental implant with high osseointegration potential.Ten dried skulls of common adult dogs, Canis familiaris, were used in this study. In order to achieve the experimental model, two working methods were performed: imaging morphometry and direct morphometry. The measurements were accomplished for the purposes of determining the dimensions of the buccal and palatal alveolar cortical bone in the target location, the maxillary premolar region. The width and height of available bone were also recorded. Data analysis was performed using Student's t-test (P ≤ 0.05) and the Stata MP/13 software.Comparable results were obtained by both imaging and direct morphometry methods. The experimental implant was customized from the dimensional point of view and considering the most appropriate implant design.
Aims: The aim of this study was to clinical evaluate the epithelial and connective tissues integration to dental implants and to describe peri-implant soft tissues response. Material and method: The study was performed on 9 dogs (Canis familiaris). Ethics Committee of The Faculty of Veterinary Medicine aproved the study. Peri-implant soft tissues were clinical evaluated regarding: the presence of keratinized mucosa around dental implants (KM), plaque index (PI), bleeding on probing (BOP), gingival index (GI). Results and discussions: The results were listed, analyzed and statistically processed. We have not found statistically significant differences regarding the indices used to evaluate soft tissues around dental implants with various timing of placement and loading protocols. The evaluation of periodontal indices showed the best results for implants applied after bone healing, irrespective of the loading protocol. Conclusions: The behavior of soft tissue around dental implants is essential for the long term success of dental implant therapy. An inadequate response is a cause of treatment failure.
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