An investigation of the constitutional adaptive gelation process of chitosan/cinnamaldehyde (C/Cy) dynagels is reported. These gels generate timely variant macroscopic organization across extended scales. In the first stage, imine-bond formation takes place "in-water" and generates low-ordered hydrogels. The progressive formation of imine bonds further induces "out-of-water" increased reactivity within interdigitated hydrophobic self-assembled layers of Cy, with a protecting environmental effect against hydrolysis and that leads to the stabilization of the imine bonds. The hydrophobic swelling due to Cy layers at the interfaces reaches a critical step when lamellar self-organized hybrids are generated (24 hours). This induces an important restructuration of the hydrogels on the micrometric scale, thus resulting in the formation of highly ordered microporous xerogel morphologies of high potential interest for chemical separations, drug delivery, and sensors.
Oral rehabilitation by dental implants is a routine treatment in the common dental practice, and volume reconstruction in cases of advanced alveolar ridge atrophy using bone autografts has become a frequently used therapeutic procedure. The study presents a histological evaluation of autogenous mandibular bone grafts integration in surgically created maxillary bone defects. Seven domestic adult dogs, Canis Familiaris were used in the study. Work methodology was established through maxillary and mandibular morphometry, the donor region being the posterior mandibular body, and the recipient region being the lateral body of the maxilla. In the experimental study, we simulated two bilateral maxillary bone defects, which were augmented with mandibular corticocancellous bone grafts. Biological samples containing the target areas were collected 90-100 days after grafting and the subsequent preparation method of the samples for histological analysis was the standard one.The histological results showed the successful integration and the beneficial effect of corticocancellous autogenous mandibular bone grafts applied in maxillary sites.
Alveolar ridge augmentation with autogenous bone grafts is a frequent procedure used in Implant Dentistry. This paper presents an immunohistochemical assessment of the integration of mandibular autografts, applied in maxillary bone defects. Seven adult dogs were used in the study. The work methodology was established through maxillary and mandibular morphometry. The posterior mandibular body was considered the donor region and the lateral region of the maxilla the recipient area. Bilateral maxillary bone defects were performed on the predetermined receiving sites, which were later augmented with mandibular grafts. Fragments of hard tissue from the grafted sites were harvested 90-100 days after the surgical interventions and immunohistochemically evaluated. The immunohistochemical study proved the existence of bone regeneration in the case of mandibular corticocancellous autografts applied at the maxillary level, being an efficient procedure for assessing their integration.
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