Introduction. Asymptomatic bacteriuria (ASB), occurring in 2–11% of pregnancies, is a major predisposition to the development of pyelonephritis, which is associated with obstetrical complications, such as preterm labor and low birth weight infants. The aim of this study was to determine the prevalence of ASB, the antibacterial susceptibilities of the isolated microorganisms and the associated risk factors in an outpatient clinical setting in Zekai Tahir Burak Women's Health Education and Research Hospital in Ankara, Turkey. Material and Methods. Between December 2009 and May 2010, pregnant women admitted to the antenatal outpatient clinic were included in this study. The results of a complete urine analysis, midstream urine culture and antibacterial susceptibility were evaluated. Results. Of the 2011 pregnant women included, 171 had ASB (8.5%). E. coli was the most frequently isolated microorganism (76.6%), followed by Klebsiella pneumonia (14.6%). Both microorganisms were highly sensitive to fosfomycin, sensivity being 99.2% for E. coli and 88% for Klebsiella pneumonia. Conclusions. In this certain geographical region, we found E. coli as the most common causative agent of ASB in the obstetric population and it is very sensitive to fosfomycin. We recommend fosfomycin for ASB in pregnant women due to its high sensitivity, ease of administration and safety for use in pregnancy.

Background Invasive fungal infections are a major cause of morbidity and mortality in preterm infants. The authors conducted the fi rst prospective, randomised controlled trial of nystatin compared with fl uconazole for the prevention of fungal colonisation and invasive fungal infection in very low birth weight (VLBW) neonates.

Clarithromycin treatment prevents development of BPD in preterm infants who are born at 750 to 1250 g and colonized with U urealyticum.

Prophylactic S. boulardii supplementation is as effective as nystatin in reducing fungal colonization and invasive fungal infection, more effective in reducing the incidence of clinical sepsis and number of sepsis attacks and has favorable effect on feeding intolerance.

Prophylactic L. reuteri supplementation is as effective as nystatin, and more effective in reducing the incidence of proven sepsis in addition to its favorable effect on feeding intolerance.

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GirişPreterm eylem tüm dünyada yeni doğan ölümleri ve konjenital anomalilerle ilişkilidir (1). Perinatal mortalitenin önde gelen sebebi olmasının yanında ortaya çıkan uzun vadeli ve ağır komplikasyonlar ve artan tedavi maliyetleri, konunun önemini artırmaktadır (2). Preterm doğan bebeklerde görme ve işitme bozuklukları, kronik akciğer hastalığı, serebral palsi ve gelişme geriliği daha sık görülmektedir (1). Perinatal morbidite ve mortalite özellikle 32. haftadan önce doğan bebeklerde görülür. Prematürite ile ilişkili hastalıklar Amerika Birleşik Devletlerinde fetal neonatal ölümlerin %70'inden fazlasının nedenidir (3).Tüm gebeliklerin %12-13'ü preterm doğumla sonlanmaktadır (4). Preterm eylem ve erken membran rüptüründe sistemik veya alt genital sistem enfeksiyonu en önemli etyolojik faktörlerdendir. Nedenler arasında ileri ya da erken anne yaşı, ekonomik durum, yetersiz prenatal bakım, geçmişte preterm eylem öyküsü, sigara içme, sık üriner sistem enfeksiyonu geçirme, stres, gebelik sırasında kanama, kronik hastalık öyküsü ve preeklampsia sayılmaktadır (5-11). İdiyopatik preterm doğumun, intrauterin enfeksiyonla ilişkili olduğu ve vajinal duş uygulamasının önemli bir risk faktörü olduğu düşünülmektedir (12, 13). Ayrıca ikinci trimesterde servikal uzunluğun azalması da risk faktörleri arasında sayılabilir (14).Erken membran rüptürü de preterm doğuma neden olabilir. Amniyon ve koryon zarlarıyla çevrili olan amniyon sıvısı, fetüse ısı transferi, fetal akciğer gelişimi, umbilikal kord ve fetüs hareketliliğini sağlar; fetüsü travmalardan Objective: To analyze the cervical culture results of pregnant women who present with normal pregnancy, preterm labor and premature rupture of membranes. Material and Methods:This study was prospectively done on 439 patients who were admitted to our hospital between January and November 2010. One hundred twenty-one were normal term pregnancies, 170 were preterm labor and 148 of them had premature rupture of membranes. The age range of the patients was 24-32 age, they were non-smokers and the mean body mass index is between 20 and 27. There was not additional disease in these patients in pre-pregnancy or pregnancy. p<0.05 was considered statistically significant.Results: Detected colonization in culture was 14.9%, 41.8%, 30.4 for normal pregnancy, preterm labor and premature rupture of membranes respectively. The most common microorganism was Escherichia coli for all groups. Colonization of microorganisms in preterm labor was statistically significant compared with normal pregnancy (p<0.001, odds ratio (OR) 4.1; 95% confidence interval (CI) 2.284-7.375). Colonization of microorganisms was also statistically significant for pregnant women with premature rupture of the membranes (p=0.003, OR 2.5; 95% CI 1.357-4.606). Conclusion:Colonization in cervical culture for preterm labor and premature rupture of membranes was statistically higher compared with normal pregnancy.Key words: Culture, preterm labor, premature rupture of membrane Amaç: Normal gebeler ile preterm eylem ve prematür membr...

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