Antenatal Cytomegalovirus Infection Screening Results of 32,188 Patients in a Tertiary Referral Center: A Retrospective Cohort Study

Sert, Yasemin; Özgü-Erdinç, A. Seval; Saygan, Sibel; Üstün, Yaprak Engin

doi:10.1080/15513815.2018.1552732

Cited by 7 publications

(9 citation statements)

References 39 publications

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“…In another study conducted with 32188 pregnant women in Ankara province between 2008 and 2017, 62% seropositivity rates were found for CMV IgG and IgM positivity was reported as 0.22%. Most of these patients had high avidity and only one infant had signs of congenital CMV infection at the time of birth (32). In our study, only one patient had low avidity rates and acute infection was not detected in this particular newborn.…”

Section: Discussioncontrasting

confidence: 56%

“…Generally, IgG seropositivity rates vary by 50-100%. When the studies performed on seropositivity in different region of Turkey were evaluated, it was observed that seropositivity for CMV IgM and IgG antibodies varied between 0.2-2.6% and 84-100%, respectively (Table II) (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)32). In our study, CMV IgM seropositivity rates was 1.9% which is similar to the other studies and CMV IgG seropositivity rates was 99.17% which is higher than most of the rates reported in previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Antenatal Toxoplasma gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital

Gürlek

Çolak

2019

Gynecol Obstet Reprod Med

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Objective: The present study was designed to determine the seroprevalance of Toxoplasma gondii, Rubella, and cytomegalovirus, to investigate the frequency of low and high avidity results among pregnant women and to contribute to the data of our country with the results obtained.Study Design: In the present study, the hospital records of the women who applied to the antenatal outpatient of the Rize Recep Tayyip Erdoğan University Medical Faculty during the first trimester between January 2016 and October 2018 were retrospectively reviewed. Toxoplasma gondii, RRubella and cytomegalovirus IgM, IgG and IgG avidity results were evaluated.Result: IgM positivity was found to be 0.83% (29/3490) for Toxoplasma gondii, 0.92% (32/3459) for Rubella and 1.90% (65/3404) for cytomegalovirus; IgG positivity was found to be 33.64% (1174/3490) for Toxoplasma gondii, 90.70% for Rubella (3140/3459), and 99.17% (3376/3404) for cytomegalovirus. Avidity of Toxoplasma gondii was found to be low (3.70%) in 1 patient, borderline (11.11%) in 3 patients, and high avidity in 23 patients (85.18%). Avidity of cytomegalovirus was found to be low (1.75%) in 1 patient, borderline (3.50%) in 2 patients and high avidity (94.73%) in 54 patients. Avidity of Rubella was found to be low (4%) in 1 patient, and high avidity (96%) was found in 24 patients.Conclusions: In our study, although the prevalence of acute infection with Rubella, cytomegalovirus and Toxoplasma gondii was shown to be low in pregnancy in Rize province, serological screening tests for monitoring and informing high-risk groups that are particularly seronegative appear to be important.

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Section: Discussioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Antenatal Toxoplasma gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital

Gürlek

Çolak

2019

Gynecol Obstet Reprod Med

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“…Human cytomegalovirus (CMV) is an ubiquitous pathogen, with a worldwide seroprevalence of 40%‐100% in the adult population . In immunocompetent individuals, CMV infection is often (80%‐95%) asymptomatic or associated with mild flu‐like symptoms .…”

Section: Introductionmentioning

confidence: 99%

The MRI spectrum of congenital cytomegalovirus infection

et al. 2020

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Human cytomegalovirus (CMV) is an ubiquitous pathogen, with a high worldwide seroprevalence. When acquired in the prenatal period, congenital CMV (cCMV) is a major cause of neurodevelopmental sequelae and hearing loss. cCMV remains an underdiagnosed condition, with no systematic screening implemented in pregnancy or in the postnatal period. Therefore, imaging takes a prominent role in prenatal diagnosis of cCMV. With the prospect of new viable therapies, accurate and timely diagnosis becomes paramount, as well as identification of fetuses at risk for neurodevelopmental sequelae. Fetal magnetic resonance imaging (MRI) provides a complementary method to ultrasound (US) in fetal brain and body imaging. Anterior temporal lobe lesions are the most specific finding, and MRI is superior to US in their detection. Other findings such as ventriculomegaly, cortical malformations and calcifications, as well as hepatosplenomegaly, liver signal changes and abnormal effusions are unspecific. However, when seen in combination these should raise the suspicion of fetal infection, highlighting the need for a full fetal assessment. Still, some fetuses deemed normal on prenatal imaging are symptomatic at birth or develop delayed cCMV-associated symptoms, leaving room for improvement of diagnostic tools. Advanced MR sequences may help in this field and in determining prognosis, but further studies are needed.

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“…C ytomegalovirus (CMV) infection is endemic worldwide, with a 30-61% seroprevalence in developed countries (1,24) and 60-100% seroprevalence in developing countries (26,31,38). CMV infection is usually acquired early in life resulting in an asymptomatic, subclinical, and mostly latent infection in immune-competent persons.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe

et al. 2019

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This study aimed to investigate the seroprevalence of cytomegalovirus (CMV) infection and risk factors associated with CMV acquisition among pregnant women in Zimbabwe. In a cross-sectional study, pregnant women were recruited in late gestation, seeking antenatal care at council clinics in three high-density suburbs in Harare, Zimbabwe. Anti-CMV IgM and IgG antibodies were quantified in serum using an enzyme-linked immunosorbent assay. Antibody avidity tests were used to distinguish active infection from viral reactivation in anti-CMV IgM-positive cases. Five hundred and twenty four women were recruited: 278 HIV infected and 246 HIV uninfected. Current or active CMV infection defined as IgM positive+low avidity was detected in 4.6% (24/524), 95% confidence interval (CI): 3–6.9 in all women, 5.8% (16/278) in the HIV infected and 3.3% (8/246), 95% CI: 1.4–6.3 in the HIV uninfected. IgG seroprevalence was 99.6% (522/524), 95% CI: 98.6–99.9 in all women. Notably, the difference in the prevalence of active CMV infection between the HIV-infected and HIV-uninfected women was not statistically significant (p = 0.173). The study shows a low prevalence of primary or active CMV infection among the pregnant women, but the IgG seroprevalence suggests high previous CMV exposure. Importantly, CMV seroprevalence was not associated with the HIV status of the women, perhaps due to the ubiquitous exposure of the population to CMV.

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Antenatal Cytomegalovirus Infection Screening Results of 32,188 Patients in a Tertiary Referral Center: A Retrospective Cohort Study

Cited by 7 publications

References 39 publications

Antenatal Toxoplasma gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital

Antenatal Toxoplasma gondii, Rubella and Cytomegalovirus Infection Screening Among Pregnant Women Attending Tertiary University Hospital

The MRI spectrum of congenital cytomegalovirus infection

Seroprevalence of Cytomegalovirus Infection Among HIV-Infected and HIV-Uninfected Pregnant Women Attending Antenatal Clinic in Harare, Zimbabwe

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