New complexes with a mixture of aspirin (acetylsalicylic acid ) with methyldopa or paracetamol with methyldopa were synthesized via the reflux of reaction mixture using a basic medium to deprotonate the ligands. These new complexes of Mn(II),Fe(II),Co(II),Ni(II) and Cu(II) with a mixture of aspirin (acetylsalicylic acid), paracetamol and methyldopa have characterized using FTIR, UV-visible spectra, magnetic susceptibility, flame atomic absorption, C.H.N.S analysis and melting points measurements. The two mixed ligands have been found to act as bidentate chelating agents. Aspirin (acetylsalicylic acid) complexes coordinate to the metal ions through the oxygen of Aspirin's ester group and oxygen of the carboxyl group, while Methyldopa as ligand is coordinated through the oxygen of the carboxyl group and the nitrogen of the amide groups. The Paracetamol was coordinated through the oxygen atom of carboxyl group and the nitrogen atom of the amide group. The stability of these new complexes depends on the size of the chelate rings, thus these ligands with a flexible organic backbone and their complexes contain five and six membered chelate rings, which have almost no strain. The molar conductance measurements for the metal complexes show non-electrolytic behavior in DMF solvent." The all-synthesized complexes which show non-electrolytic properties, also were no conducting electrical current behaved as bi-dentate with octahedral geometrical isomers.
An accurate, simple, and sensitive indirect spectrophotometric method which proposed and developed for the determination of paracetamol in different pharmaceutical preparations. The proposed method was based on acid hydrolysis of PAR to produced p-aminophenol (PAP), PAP was diazotization with nitrite ion to form the corresponding diazonium salt, followed by coupling with histidine reagent in alkaline medium to produced azo dye that showed maximum absorbance at 430 nm. Beer's law was obeyed in the concentration rage of 10-500 µg/20 ml (i.e. 0.5-25 ppm). The molar absorpitivity and Sandell's sensitivity of the dye were. 1.118×10 4 l.mol-1 .cm-1 and 0.0135 µg.cm-2 respectively. The method successfully has been applied for the determination of PAR in pure form,and its pharmaceutical preparations (tablets, syrup and injection).
Background: The eco-friendly power of hydrogen peroxide oxidant produced water that was the only by-product after oxidation. Unfortunately, its oxidation power towards chalcones and chalcones analogs was substantially low, and therefore, it was normally used together with a catalyst or converted to hydroperoxides in order to improve its oxidation power.Objective: This research aimed to study epoxidation chemistry. Hence, hydrogen peroxide was used as a potential oxidant for epoxidation with different techniques and catalysts. Methodology: Advantageous effects of (reline) (derived from two moles of choline chloride and one mole of urea) as a deep eutectic solvent (DES) or the gold (Au) catalyst nanoparticles (NPs) supported on titanium oxide (Au-TiO2) on the chalcone derivatives of peroxidation was studied under several procedure conditions using hydrogen peroxide/sodium bicarbonate to produce novel oxiranes (I-VI). Results and Discussion: Acceptable results were obtained by method (B) using hydrogen peroxide/sodium bicarbonate -(reline) mixture, which gave 87-90% peroxidation results in a short time (4 h) in comparison with less than 86% and 24 h of the conventional method (A), while using the Au NPs supported on titanium oxide (Au-TiO2); that is, Method (C) gave the best percentage yield of 90-95 % and time (about 2 h), which is about half of that of (Reline) mixture. Such a condition may be due to high activation of hydrogen peroxide by Au and titanium oxide nanoparticles and low viscosity of the reaction mixture. Conclusions: The chalcones epoxidations would convince chemists that using the deep eutectic solvent (Reline) and the Ausupported on titanium oxide NPs for catalysing these reactions are techniques of great importance in various branches of oxidation.
Chroman-4-one derivatives 1(a-i) were prepared by Pechman condensation of phenol or its substitutions with cinnamic acid by using polyphosphoric acid. These derivatives were reacted with hydrazine hydrate in refluxing ethanol to yield pyrazoline derivatives (2). The utility
The new heterocyclic compounds 1,5-Dimethyl-2-phenyl-4-(5-aryl-4,5-dihydro-1Hpyrazol-3-ylamino)-1,2-dihydropyrazol-3-ones (iiia-b) and 1,5-dimethyl-2-phenyl-4-(5-aryl-4,5-dihydroisoxazol-3-ylamino)-1,2-dihydropyrazol-3-ones (iva-b) were synthesized in the first route in this work by refluxing ethanolic solution of hydrazine hydrate with N-(1,5dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)cinnamamid (iia) or (E)-3-(4chlorophenyl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl) acrylamide (iib) respectively. These unsaturated amides were prepared by the reaction of benzaldehyde or 4chlorobenzaldehyde with N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4yl)acetamide (i) in refluxing methanol. This acetamide was prepared by reaction of 4-AAP with acetyl chloride or with acetic anhydride. In the second route 1,7-dimethyl-2-phenyl-hexahydro-6H-pyrazolo[4,3-e][1,2,4]triazine-3,5-dione (vii) was synthesized by refluxing ethanolic solution of hydrazine hydrate (in presence of pyridine) with ethyl 1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4ylcarbamate (vi). This carbamate was synthesized by the reaction of 4-AAP with pyridine or anhydrous sodium carbonate. Finally, the reaction of 4-AAP with benzaldehyde or its 4-chloro derivative afforded the corresponding Schiff bases (va-b). The structure of these compounds was confirmed by IR & UV Spectra, in addition to the CHN elemental analysis.
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