Preparation of New Complexes from a Mixture of Aspirin (acetylsalicylic acid), Paracetamol and Methyldopa with Divalent Manganese , Iron, Cobalt, Nickel and Copper, With a Study of Their Physical and Chemical Properties.

Abstract

New complexes with a mixture of aspirin (acetylsalicylic acid ) with methyldopa or paracetamol with methyldopa were synthesized via the reflux of reaction mixture using a basic medium to deprotonate the ligands. These new complexes of Mn(II),Fe(II),Co(II),Ni(II) and Cu(II) with a mixture of aspirin (acetylsalicylic acid), paracetamol and methyldopa have characterized using FTIR, UV-visible spectra, magnetic susceptibility, flame atomic absorption, C.H.N.S analysis and melting points measurements. The two mixed ligands have been found to act as bidentate chelating agents. Aspirin (acetylsalicylic acid) complexes coordinate to the metal ions through the oxygen of Aspirin's ester group and oxygen of the carboxyl group, while Methyldopa as ligand is coordinated through the oxygen of the carboxyl group and the nitrogen of the amide groups. The Paracetamol was coordinated through the oxygen atom of carboxyl group and the nitrogen atom of the amide group. The stability of these new complexes depends on the size of the chelate rings, thus these ligands with a flexible organic backbone and their complexes contain five and six membered chelate rings, which have almost no strain. The molar conductance measurements for the metal complexes show non-electrolytic behavior in DMF solvent." The all-synthesized complexes which show non-electrolytic properties, also were no conducting electrical current behaved as bi-dentate with octahedral geometrical isomers.

4N donor atoms moiety of transition metal complexes of a Schiff base ligand: Synthesis, characterization and biological activities study

“…The IR spectra of the metal complexes displayed that, the ν(C=N)imine stretching frequency undergone a shift to lower frequency by (2 -27) cm-1. This shift indicates to coordination of the azomethine nitrogen to the metal ion [30,31]. The ν(C=O) of the carbonyl group appeared in the 1735 -1705 cm-1 range.…”

Preparation of New Complexes of Bivalent Manganese, Iron, Cobalt, and Nickel with Mixed Ligands of Ciprofloxacin (Cip) and Metronidazole (Met) or 4-Aminoantipyrine (4AAP) with Study of Their Chemical, Physical Properties and Antibacterial Activity

“…Antibacterial activity of new complexes is subjected on Escherichia coli, Pseudomonas aeruginosa via using disc diffusion method in DMSO. [27][28][29]The results are listed in table 7. Role of negative results are effective so, all new complexes exhibited no activity against Escherichia coli, Pseudomonas aeruginosa except complex 2a,d .…”

Comparative Synthesis, Spectral and Antimicrobial Studies of Metal (Ii) Complexes Derived From Aspirin

“…Synthetic research on complexes from ligands and transition metals have been of great interest to the chemists especially as the antimicrobial activity of the ligands (drugs) with transition metals plays important role in their complexation and their activity [1]. As many investigations have been carried out for both solution based and solid state synthesis of the ligands metal complexes as those by [2]; [3]; [4] and so on.…”