Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction

Alubaidy, Ghassan F.; Basheer, Asma A.; Saied, Shakir M.; Thanoon, Enas S.

doi:10.33899/rjs.2019.159979

Cited by 4 publications

(4 citation statements)

References 6 publications

(2 reference statements)

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“…These methods included HPLC [5][6][7],electrochemical [8,9], flow injection [10], and flurometric [11]. The spectrophotometric methods included various types of reactions such as diazotization of p-aminophenol resulted from hydrolysis of paracetamol then coupled with various coupling agent such as 4 [(2-amino-1, 3thiazol-4-yl) amino] nitrobenzene [12], histidine reagent in alkaline medium [13], 1-naphthol [14], 2, 7-dihydroxy naphthalene in alkaline medium [15], hydroxyl analog of the pharmaceutical naproxen [16], phloroacetophenone in an alkaline medium [17]. The oxidative coupling methods have been used with different reagent such as using N-(1-naphthyl) ethylendiamine dihydrochloride in presence of potassium iodate [18], chlorocresol in the presence of dissolved atmospheric oxygen and sodium carbonate [19] and 2, 5-di-hydroxy benzaldehyde in presence of potassium periodate as oxidizing agent [20], oxidation and bleaching color of dye: oxidation with N-bromosuccinimide and bleaching color of rifampicin [21], with bromosuccinimide and bleaching color of Eriochrom Black-T [22].…”

Section: Scheme 1 Acid Hydrolysis Of Parlmentioning

confidence: 99%

Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol

Alhafid¹,

Otman²

2021

J.Edu.Sci.

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A simple and sensitive spectrophotometric method has been suggested for the estimation of pure paminophenol(p-AMPL), and p-AMPL results from the hydrolysis of paracetamol (PARL). The suggested method is based on oxidative coupling reaction of p-AMPL with 4-chlororesorcinol and potassium periodate to produce a stable, and water-soluble colored product with maximum absorption at wavelength 556 nm. Beer's law is followed over the range of concentration from 2 to 20 µg. ml-1. The molar absorptivity value is equal to 1.0356×104 l.mol-1cm-1. All factors responsible for the completed reaction and highest intensity of the product have been studied, and the optimal of each factor has been selected. The suggested method was applied in an indirect method for the determination of paracetamol in tablets and injection after acidic hydrolysis to p-AMPL. The common excipients added did not interfere in the estimation of paracetamol.

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Section: Scheme 1 Acid Hydrolysis Of Parlmentioning

confidence: 99%

Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol

Alhafid¹,

Otman²

2021

J.Edu.Sci.

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“…The percentage recoveries were found to the range from 98.20 -100.40. The outcomes were compared with the reference method 36,41 (Tab. 5).…”

Section: Applicationsmentioning

confidence: 99%

“…These techniques are titrimetric 12 , HPLC and RP-HPLC [13][14][15] , HPTLC 16 , Voltametric [17][18][19][20] , electrochemical 21 and spectrophotometry 10 . Several spectrophotometric techniques for the determination of paracetamol are presented in the literature 10,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] .…”

Section: Introductionmentioning

confidence: 99%

Determination of paracetamol in pharmaceutical samples by spectrophotometric method

Pasha

2020

Eclet. Quim. J.

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It is described the use of 1,3 dinitrobenzene or 2,4 dinitrophenyl hydrazine is used as coupling agent for the spectrophotometric determination of paracetamol. This method is easy and simple based on the reaction of acid hydrolysis of paracetamol to produce p-aminophenol, which in turn reacts with nitrite in acidic standard to form diazonium ion, which is coupled with coupling agent in basic standard to produce azo dyes. The formed dyes follow Beer’s law in the range of 0.8-20.5 mg mL-1 of paracetamol with 1, 3 dinitrobenzene or 0.5-18.4 mg mL-1 of paracetamol with 2,4 dinitrophenyl hydrazine with absorption maxima at 429 nm or 430 nm. The molar absorptivity and Sandell’s sensitivity of paracetamol with 1,3 dinitrobenzene or paracetamol with 2,4 dinitrophenyl hydrazine azo dyes were 1.965×104 L mol-1 cm-1 or 2.776×104 L mol-1 cm-1, and 7.692×10-3 mg cm-2 or 5.698×10-3 mg cm-3 respectively. The dyes formed are stable for more than 12 h. The optimal reaction circumstances and other analytical parameters are evaluated. Interference due to foreign organic compounds have been studied. The method has been effectively applied to the determination of paracetamol in pharmaceutical samples.

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“…Paracetamol, also known as acetaminophen or N-(4hydroxyphenyl)acetamide, is widely recognized for its analgesic and antipyretic properties [1,2]. As an active ingredient in various pharmaceutical formulations, it enjoys extensive global usage due to its high efficacy, minimal side effects, and lower toxicity compared to other drugs [3].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a RP-HPLC Method for Simultaneous Quantification of Paracetamol and Phenylephrine Hydrochloride

Al-Samarrai,

Lafta,

Al-Abbasee

et al. 2024

IJDNE

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A rapid, accurate, and sensitive method for the simultaneous quantification of paracetamol and phenylephrine hydrochloride was developed using RP-HPLC. The procedure utilized a NUCLEODUR® C18 separating column (250 × 4.6 mm id) with a flow rate of 0.8 mL/min and a column temperature of 25℃. The detector wavelength was set at 234 nm, and the injection volume was 20 μL. The mobile phase consisted of a mixture of acetonitrile and buffer solution (45 mM orthophosphoric acid, and the pH was adjusted to 6 using a 10% (w/v) sodium hydroxide solution) in a 52:48 v/v ratio. The method was validated with recovery percentages ranging from 99.36 to 105% for paracetamol and 99.78 to 100.8% for phenylephrine. The correlation coefficients were 0.9999 for both compounds, with linearity ranges of 2-100 µg/mL for paracetamol and 5-80 µg/mL for phenylephrine. This method has been successfully applied to the simultaneous quantification of these drugs in pharmaceutical preparations available in the local market.

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Spectrophotometric Determination of Paracetamol Using Diazotization Coupling Reaction

Cited by 4 publications

References 6 publications

Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol

Spectrophotometric estimation of para-aminophenol via oxidative coupling reaction with 4-chlororesorcinol –Application to paracetamol

Determination of paracetamol in pharmaceutical samples by spectrophotometric method

Development and Validation of a RP-HPLC Method for Simultaneous Quantification of Paracetamol and Phenylephrine Hydrochloride

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