BACKGROUND. Cardiovascular disease occurs at lower incidence in premenopausal females compared with age-matched males. This variation may be linked to sex differences in inflammation. We prospectively investigated whether inflammation and components of the inflammatory response are altered in females compared with males.METHODS. We performed 2 clinical studies in healthy volunteers. In 12 men and 12 women, we assessed systemic inflammatory markers and vascular function using brachial artery flow-mediated dilation (FMD). In a further 8 volunteers of each sex, we assessed FMD response to glyceryl trinitrate (GTN) at baseline and at 8 hours and 32 hours after typhoid vaccine. In a separate study in 16 men and 16 women, we measured inflammatory exudate mediators and cellular recruitment in cantharidin-induced skin blisters at 24 and 72 hours.RESULTS. Typhoid vaccine induced mild systemic inflammation at 8 hours, reflected by increased white cell count in both sexes. Although neutrophil numbers at baseline and 8 hours were greater in females, the neutrophils were less activated. Systemic inflammation caused a decrease in FMD in males, but an increase in females, at 8 hours. In contrast, GTN response was not altered in either sex after vaccine. At 24 hours, cantharidin formed blisters of similar volume in both sexes; however, at 72 hours, blisters had only resolved in females. Monocyte and leukocyte counts were reduced, and the activation state of all major leukocytes was lower, in blisters of females. This was associated with enhanced levels of the resolving lipids, particularly D-resolvin.CONCLUSIONS. Our findings suggest that female sex protects against systemic inflammation-induced endothelial dysfunction. This effect is likely due to accelerated resolution of inflammation compared with males, specifically via neutrophils, mediated by an elevation of the D-resolvin pathway.TRIAL REGISTRATION. ClinicalTrials.gov NCT01582321 and NRES: City Road and Hampstead Ethics Committee: 11/LO/2038.FUNDING. The authors were funded by multiple sources, including the National Institute for Health Research, the British Heart Foundation, and the European Research Council.

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Purpose The purpose of this study was to explore the essential digital competencies for developing and managing digital libraries. The study identified useful training programs for university librarians to acquire digital competencies. It examined their digital competencies for developing and managing digital libraries in universities of Pakistan. This study also evaluates their digital knowledge in applying security measures to protect digital contents. Design/methodology/approach The quantitative research method was used to conduct this study. Research questions and hypothesis were developed to achieve the objectives. In-depth review of related literature was conducted to draft a list of essential digital competencies for developing and managing digital libraries. It was circulated among the panel of experts to get their valuable feedback to make a final list of digital competencies for developing and managing digital libraries. A questionnaire was developed to measure the status of digital competencies of university librarians in Pakistan. It was pre-tested on 20 respondents before applying to the whole population. SPSS software was used to analyze data. Descriptive and inferential statistics were applied to achieve results. Findings The findings of the study showed that digital competencies for developing and managing digital libraries fall into three main categories: digital competencies for developing digital libraries; digital competencies for managing digital libraries; and digital competencies to protect digital contents. The results revealed that training programs offered by Higher Education Commission (HEC), library associations, library schools, in-house trainings, use of online tutorials and trainings offered by skilled professionals are highly important and useful for university librarians to acquire digital competencies. The study concluded that the university librarians working in HEC recognized universities in Punjab province possess basic level of digital competencies for developing and managing digital libraries. Their digital competencies vary on the basis of their university type, i.e. public and private sector. Research limitations/implications This study measures digital competencies of university librarians in Pakistan. The study has practical implications for librarians, library schools, library associations, university libraries and HEC. Practical implications This study has practical implications for librarians, information professionals, libraries and library schools. The results are useful for librarians to get knowledge of digital competencies which are essential for developing and managing digital libraries and protecting digital contents. They can develop their digital competencies in identified areas. This study has identified useful training programs for university librarians for acquiring digital competencies. The university librarians should use these programs to gain needed digital skills. Social implications Librarians can get knowledge of digital competencies for developing and managing digital libraries to face the challenges of digital age. Originality/value In contrast to previous research work on investigating computer skills, information and communication technology skills, technological skills and general digital skills, this study particularly identifies the essential digital competencies for developing and managing digital libraries. It helps library and information science schools, library associations, training groups and university libraries to offer adequate training opportunities in identified areas to meet the challenges of the digital age.

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PurposeMajor objective of the instant study was to investigate the factors affecting the adoption of integrated semantic digital libraries (SDLs). It attempted to find out the challenges faced in implementing semantic technologies in digital libraries. This study also aimed to develop a framework to provide practical solutions to efficiently adopt semantic digital library systems to offer richer data and services.Design/methodology/approachTo meet the formulated objectives of the study, a systematic literature review was conducted. The authors adhered to the “Preferred Reporting Items for the Systematic Review and Meta-analysis” (PRISMA) guidelines as a research method. The data were retrieved from different tools and databases. In total, 35 key studies were included for systematic review after having applied standard procedures.FindingsThe findings of the study indicated that SDLs are highly significant as they offered context-based information resources. Interoperability of the systems, advancement in bilateral transfer modules, machine-controlled indexing, and folksonomy were key factors in developing semantic digital libraries. The study identified five different types of challenges to build an integrated semantic digital library system. These challenges included ontologies and interoperability, development of a suitable model, diversity in language, lack of skilled human resources, and other technical issues.Originality/valueThis paper provided a framework that is based on practical solutions as a benchmark for policymakers to devise formal standards for the initiation to develop integrated semantic digital libraries.

Purpose The purpose of this paper is to explore useful Semantic Web technologies and ontology-based applications for digital libraries. It also investigates the perceptions of university librarians and academicians in Pakistan about Semantic Web technologies and their use in digital libraries. Design/methodology/approach An exploratory research design based on Delphi research strategy was conducted to answer the research questions. Interviews were conducted with a purposive sample of 50 key informants including university librarians and academicians to explore their perceptions about Semantic Web technologies and their use in digital libraries. Thematic analysis of interview data was conducted to obtain results. Findings The results of this paper showed that DuraCloud, Semantic information mashup, OntoEdit and resource description framework (RDF) are the various Semantic Web applications which are useful for digital libraries to develop semantic relationships among digital contents and increase their accessibility in the web environment. Findings revealed that Semantic Web provides precise results and meets user information needs in an effective way. Results also showed that next-generation digital libraries use context-awareness technology, intelligent agent software and detecting sensors to analyze user information needs and provide dynamic information services. This paper recommended that librarians should embrace the use of emerging web technologies in libraries and offer library services through the medium of the web. Practical implications This paper envisaged the future of digital library services and Semantic Web applications that can be used to re-structure metadata of digital library. This paper has practical implications for librarians to consider the useful applications of Semantic Web for digital library and enhance the interoperability of metadata among heterogeneous information systems. Practically, results obtained from this paper are highly useful for library schools and LIS teachers to up-date their curriculum by incorporating new contents related to web languages and Semantic Web applications for digital libraries. Originality/value This paper identifies various Semantic Web applications which are useful for developing Semantic Digital Libraries.

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PurposeThe purpose of this study is to investigate the key features of information management systems (IMSs) for automation in university libraries. This study also highlights the use of library information management systems in university libraries and the satisfaction of university librarians in using various IMS.Design/methodology/approachThis study is quantitative in nature. A survey research method has been applied to achieve the research objectives. Purposive sampling has been used to select the targeted population which consisted of 157 librarians working in university libraries. Data were collected through a web-based questionnaire. Descriptive and inferential statistics were applied to analyze the collected data by using SPSS software.FindingsFree and open source software are widely used in university libraries to manage the bibliographic information of library material. KOHA is the most used software for library automation in university libraries of Pakistan. The key features of library information management system (IMS) include reliability and security of the software, user-friendly interface, advance searching options, use of library standards (MARC, Uni MARC, RDA), online upgradation, technical support of developing company, shared cataloging, multilingual features of software, etc (See Figure 4). The study recommends that the above-mentioned features must be considered by university librarians when selecting any software for library automation. Results showed that apart from the use of KOHA software, there are also some other software which are being used for library automation in university libraries of Pakistan. These systems include; Virtua, Library Management System (LMS), and Library Information Management Systems (LIMSs).Practical implicationsThis study has practical implications for university librarians in Pakistan as well as in other countries. Librarians can use the results of this study as a blueprint before selecting any information management system to automate the library record.Originality/valueThis study identifies the core features of IMS for automation in libraries. These features have been recommended by informational professionals who have been working in automated libraries and possess adequate professional experience in using library automation software.