We aimed to investigate effects of vitamins C and E (VCE) supplementation with exercise (EX) on antioxidant vitamin and lipid peroxidation (LP) levels in blood of patients with fibromyalgia (FM). A controlled study was performed on blood samples from 32 female FM patients and 30 age-matched controls. The patients were divided into three groups namely EX (n = 10), VCE (n = 11), and EX plus VCE (n = 11) after taking basal blood samples. After 12 weeks of EX and VCE supplementation, blood samples were taken once more from the patients. LP levels in plasma and erythrocytes were higher in the patients at baseline than those in controls, whereas LP levels were lower in the VCE and EX groups at the end of 12 weeks than those at baseline. Plasma concentrations of vitamins A and E and reduced glutathione were lower in the patients than those in controls and their concentrations were increased by VCE and EX. Glutathione peroxidase activity in erythrocytes was increased by VCE supplementation, with or without EX. Concentrations of β-carotene in the groups did not change with treatment. Despite the measured effects on anti-oxidative mechanisms, FM symptoms were not improved by the treatments. In conclusion, VCE with EX may protect against FM-induced oxidative stress by up-regulation of an antioxidant redox system in the plasma and erythrocytes of patients with FM. Such protective effects of VCE in the patients seemed to be greater in combination with EX than EX alone.
To investigate the efficacy of phonophoresis with nonsteroid anti-inflammatory drugs (P-NSAID) and corticosteroids (P-CS) in the treatment for carpal tunnel syndrome (CTS) and to compare the efficacy of phonophoresis with local CS injection (LCSI) and splinting with a 3-month follow-up. 84 hands of 51 patients with CTS were treated by applying LCSI, P-CS, P-NSAID, and wrist splinting. Electrophysiological studies, grip strength, hand dexterity, and sensory recovery of the first three digits were assessed. Duruöz hand index (DHI) was used to assess the functional hand disability. For clinical evaluation, we used Phalen and Tinnel signs. Pain intensity was evaluated by visual analog scale. The LCIS group showed a significant improvement in pain relief and DHI, but this group had significant deterioration in the results of monofilament and pegboard tests. The P-CS group showed improvement in sensory nerve conduction velocity, distal latency, grip strength, and DHI parameters. There was a significant improvement in grip strength, pegboard test, and pain intensity in the P-NSAID group. There was improvement only in pain intensity in the splinting group. We identified marked improvement in the electrophysiological studies in the P-CS group. Splinting had no effect on hand functions, disability, and electrophysiological studies.
The etiology of fibromyalgia is not clearly understood. In recent years, a few studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of fibromyalgia. The aim of this study was to investigate plasma antioxidant vitamins, lipid peroxidation (LP), and nitric oxide (NO) levels in patients with fibromyalgia and controls. The study was performed on the blood plasma of 30 female patients and 30 age-matched controls. After a fast of 12 h, blood samples were taken, and plasma samples were obtained for measurement of vitamins A, C, E, and beta-carotene concentrations and levels of LP and NO. Concentrations of vitamins A (p < 0.01) and E (p < 0.001) were significantly lower in patients with fibromyalgia than in controls, and LP levels were significantly (p < 0.05) higher in the plasma of the patients than in controls. Concentrations of vitamin C and beta-carotene and levels of NO did not change significantly. These results provide some evidence for a potential role of LP and fat-soluble antioxidants in the patients with fibromyalgia.
Japanese women now account for 43 percent of the labor force. A number of them are involved in construction, agricultural and forestry jobs. The aim of this study was to establish a non-invasive technique for the evaluation of peripheral circulatory functions in women with Raynaud's phenomenon (RP) and introduce a specific method for the assessment of vascular disturbances in females exposed to hand-transmitted vibration. The subjects of this study were 10 women with primary RP, 7 women with progressive systemic sclerosis (PSS) secondary to RP, and 17 females who were included as the control group. The evaluation of peripheral circulatory functions in all subjects was based on the values of finger blood flow (FBF) and finger skin temperature (FST) measured before, during and following a 5-min recovery period after the hand was immersed in cold water (5°C, 1 min). The measured values of FBF and FST of the primary RP group before and after the immersion test were significantly (p < 0.01) lower compared to those of the control group. The technique applied in this study could be used as a non-invasive and tolerable technique to determine the digital circulatory functions in female subjects with RP.
Objectives: Polycystic ovary syndrome [PCOS] is one of the most common reproductive abnormalities and is characterized by hyperandrogenemia. We aimed to assess the frequency of fibromyalgia syndrome [FMS] and psychological distress in patients with PCOS. Methods: Forty patients with PCOS and 39 age-matched healthy controls were included in the study as PCOS and healthy normal control [HNC] groups. The diagnosis of FMS was based on the American College of Rheumatology criteria of 1990, and the diagnosis of PCOS was based on the Rotterdam criteria of 2003. All participants completed the questionnaires to gather information including demographic features, FMS-related symptoms, and the psychological status. Patients with PCOS were divided into two subgroups according to coexistence of FMS [PCOS only and PCOS + FMS]. Results: The mean age of PCOS and HNC groups were 23.97 ± 6.01 and 26.15 ± 5.45 years, respectively [P > 0.05]. The frequency of FMS in PCOS and HNC groups was 32.5 percent and 7.7 J Muscoskeletal Pain Downloaded from informahealthcare.com by Universitat de Girona on 11/03/14 For personal use only.Soyupek et al. 121 percent, respectively [P < 0.05]. Except constipation and paresthesia, the presence of FMS-related symptoms in the PCOS + FMS subgroup were higher than those of the PCOS only subgroup and HNC group. There were no differences in depression scores between the PCOS only and PCOS + FMS subgroups, but there were differences in anxiety scores.Conclusion: The frequency of FMS was found to be increased in PCOS. Anxiety risk was also found to be increased, particularly in patients with PCOS and concomitant FMS. KEYWORDS.Polycystic ovary syndrome, fibromyalgia syndrome, anxiety, depression * P < 0.05 for PCOS + FMS versus PCOS only subgroups. * * P < 0.05 for PCOS + FMS versus HNC. * * * P < 0.05 for PCOS only versus HNC. PCOS + FMS = coexistence of polycystic ovary syndrome with fibromyalgia syndrome. HNC = healthy normal controls, FSH = follicle stimulating hormone, LH = luteinizing hormone, DHEA-S = dehydroepiandrosterone sulfate. J Muscoskeletal Pain Downloaded from informahealthcare.com by Universitat de Girona on 11/03/14For personal use only.
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