The Frequency of Fibromyalgia Syndrome in Patients with Polycystic Ovary Syndrome

Abstract

Objectives: Polycystic ovary syndrome [PCOS] is one of the most common reproductive abnormalities and is characterized by hyperandrogenemia. We aimed to assess the frequency of fibromyalgia syndrome [FMS] and psychological distress in patients with PCOS. Methods: Forty patients with PCOS and 39 age-matched healthy controls were included in the study as PCOS and healthy normal control [HNC] groups. The diagnosis of FMS was based on the American College of Rheumatology criteria of 1990, and the diagnosis of PCOS was based on the Rotterdam criteria of 2003. All participants completed the questionnaires to gather information including demographic features, FMS-related symptoms, and the psychological status. Patients with PCOS were divided into two subgroups according to coexistence of FMS [PCOS only and PCOS + FMS]. Results: The mean age of PCOS and HNC groups were 23.97 ± 6.01 and 26.15 ± 5.45 years, respectively [P > 0.05]. The frequency of FMS in PCOS and HNC groups was 32.5 percent and 7.7 J Muscoskeletal Pain Downloaded from informahealthcare.com by Universitat de Girona on 11/03/14 For personal use only.Soyupek et al. 121 percent, respectively [P < 0.05]. Except constipation and paresthesia, the presence of FMS-related symptoms in the PCOS + FMS subgroup were higher than those of the PCOS only subgroup and HNC group. There were no differences in depression scores between the PCOS only and PCOS + FMS subgroups, but there were differences in anxiety scores.Conclusion: The frequency of FMS was found to be increased in PCOS. Anxiety risk was also found to be increased, particularly in patients with PCOS and concomitant FMS. KEYWORDS.Polycystic ovary syndrome, fibromyalgia syndrome, anxiety, depression * P < 0.05 for PCOS + FMS versus PCOS only subgroups. * * P < 0.05 for PCOS + FMS versus HNC. * * * P < 0.05 for PCOS only versus HNC. PCOS + FMS = coexistence of polycystic ovary syndrome with fibromyalgia syndrome. HNC = healthy normal controls, FSH = follicle stimulating hormone, LH = luteinizing hormone, DHEA-S = dehydroepiandrosterone sulfate. J Muscoskeletal Pain Downloaded from informahealthcare.com by Universitat de Girona on 11/03/14For personal use only.

Relationship of Body Image Concerns with some Gynecological Diseases and Chronic Fatigue Syndrome: A Review

“…A history of polycystic ovarian syndrome, hirsutism, and ovarian cysts were reported more often in patients with CFS compared with controls. Soyupek et al (2010) aimed to assess the association between fibromyalgia syndrome and psychological distress in patients with PCOS. The results concluded that the frequency of FMS as well as anxiety risk was found to be increased in PCOS.…”

Evaluation of Bodily Pain Associated with Polycystic Ovary Syndrome: A Review of Health-Related Quality of Life and Potential Risk Factors

“…The relationship between IR and chronic pain has been established [ 104 ], and obesity can also increase the prevalence of chronic pain [ 105 , 106 ]. IR is also associated with fibromyalgia syndrome [ 107 ]; this pathophysiology was reported in a population of patients with PCOS who exhibited an increased frequency of fibromyalgia [ 108 ], which is a widespread pain anomaly characterized by a decreased pain threshold. A patient with fibromyalgia may experience musculoskeletal pain accompanied by an increased frequency of disorders pertaining to sleep, fatigue, mood, and memory.…”