Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.
Objective: Evaluation of ethanolic extract of Diospyrous malabarica Desr. Bark for anti-diabetic and antioxidant potentials. Materials and Methods: Diospyros malabarica Desr. bark ethanol extract was studied for the OGTT study and acute and sub-acute effects on alloxan induced diabetic rats. Blood glucose levels, Serum lipid profiles and histopathological study of pancreas were performed. The Bark extract was also studied for DPPH radical scavenging potential. Results: Ethanolic extract of bark of Diospyros malabarica significantly improved the glucose tolerance test upto 4h., approximately, 17% and 29% reduction in blood glucose level was observed at 2 h and 4 h respectively. Blood glucose lowering potential percentage was 19% at 6 h in acute studyand after 15 days of treatment it was 39% in Sub acute study. The extract also showed better activity in quenching DPPH radical. Conclusion: Ethanolic extract (200 mg /kg) treated diabetic rats showed partial restoration of normal cellular population and size of islet cells.
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