Screening of Ethanolic Extract of Diospyros malabarica Desr. Bark for Anti-diabetic and Antioxidant Potential.

Kavatagimath, Satish Annayya; Jalalpure, Sunil

doi:10.5530/ijper.50.1.22

Cited by 5 publications

(2 citation statements)

References 12 publications

(3 reference statements)

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“…On the other hand, the highest yield obtained in bark extracts amongst other plant parts demonstrated that D. malabarica bark extracts are a superb source of phytochemicals. Accordingly, the methanol, most polar solvent after water as testified formerly due to exhibiting more extraction yield, might be responsible to reflect more presence of phytochemicals and effective solvent in evaluation of potent biological activities [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study of Diospyros malabarica (Gaub) Extracts in Various Polarity-Dependent Solvents for Evaluation of Phytoconstituents and Biological Activities

Zreen

Hameed

Kiran

et al. 2022

BioMed Research International

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Keeping in mind the ascribed repute of Diospyros malabarica (D. malabarica), this investigation was commenced to assess the effect of diverse solvents on extraction yields, phytochemical components and antioxidant capability, and in vitro biological activities of D. malabarica for pharmaceutically active constituents to combat various infections. To screen phytochemicals both qualitatively (flavonoids, terpenoid, saponins, tannins) and quantitatively like total phenolic and flavonoid contents, Diospyros malabarica parts include the following: root, leaves, bark, stem, ripe, and unripe fruit were sequentially extracted with organic solvents such as petroleum ether, dichloromethane, ethyl acetate, ethanol, methanol, and water in increasing order of polarity from less polar to more polar solvents. Furthermore, biological activities such as antibacterial, antifungal, anticancer, antidiabetic, and anti-inflammatory were explored. The results revealed that all the tested solvents displayed a vital role in the extraction yield, the content of phytochemicals, and the studied biological activities. Methanol was found as the best solvent followed by the ethanol for the extraction, representing the highest extraction yield (18.3%), rich diversity of phytochemicals, and the highest total phenolic contents ( 602 ± 0.001 μ g EAG/mg of extract) and total flavonoid contents ( 455 ± 0.6 μ g EQ/mg of extract) in bark extract. Furthermore, methanol bark extract showed high in vitro antibacterial activity ( 30.25 mm ± 0.9 ), antifungal activity ( 18.25 mm ± 0.2 ), anticancer activity (48%), antidiabetic activity (68%) and anti-inflammatory activity (62%) followed by ethanol amongst other extracts of D. malabarica. Accordingly, methanol might be as an ideal solvent to get maximum content of phytochemicals, promising antioxidants, and in vitro biological activities from bark extract amongst other extracts of D. malabarica compared to pet ether, ethyl acetate, and dichloromethane and may act as free radical rummager because phytochemical constituents exhibit antioxidant capability. Our findings suggest that phytochemical compounds (flavonoids, tannins, phenols, saponins, and terpenoids) found in the bark extract of D. malabarica may be attributed to evaluate potent anti-inflammatory, anticancer, antidiabetic, antibacterial, and antifungal activities.

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Section: Resultsmentioning

confidence: 99%

A Comparative Study of Diospyros malabarica (Gaub) Extracts in Various Polarity-Dependent Solvents for Evaluation of Phytoconstituents and Biological Activities

Zreen

Hameed

Kiran

et al. 2022

BioMed Research International

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“…The methanol extract of the leaves and stem bark of D. malabarica obtained by maceration have previously shown anti-diabetic activity by inhibiting α-amylase. 15 In addition, in vivo studies on the methanol extract of the leaves and stem bark of D. malabarica have shown a significant hypoglycaemic effect, 16,17 and good antioxidant activity. 10 Based on a review of previous studies, extraction using ultrasoundassisted extraction (UAE) of D. malabarica has not been reported.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents, Anti-Diabetic and Antioxidant Activities of Methanol Extracts of Diospyros malabarica (Desr.) Kostel Leaves and Stem Bark

2024

TJNPR

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Therefore, there is the need for a therapeutic agent that will reduce glucose absorption by inhibiting the action of carbohydrate hydrolyzing enzymes such as α-glucosidase, 2,3 inhibiting the action of the DPP-4 enzyme which plays a role in reducing glucagon secretion and stimulating insulin secretion from the pancreas, 2 and scavenging free radicals. Diabetes mellitus and its complications are associated with increased oxidative stress caused by free radicals. 3 Free radicals are compounds with unpaired electrons which make them unstable and very reactive. In order to attain a paired electron state and become stable, free radicals oxidizes biomolecules and cell organelles, thus inducing cell damage. 4 Most free radicals in the body are reactive oxygen species (ROS) consisting of superoxide anion (O2•-), alkoxyl radical (RO•) radical, hydroxyl radical (OH•), peroxyl radical (ROO•), and hydroperoxyl radical (HO2•), while nitric oxide (NO•), nitrite (NO2•), and nitrate radicals (NO3•) are termed the reactive nitrogen species (RNS). 5 Free radical activity causes physiological disturbances in cells; therefore, antioxidants are needed to neutralize or mitigate free radical levels to maintain cell physiological functions and contribute to disease prevention. Antioxidant activity protects the body against the damaging effects of oxidative stress due to hyperglycemia and can improve carbohydrate, protein and lipid metabolism and glucose absorption in people with diabetes mellitus. 6 Currently, several types of drugs are available for the treatment of diabetes including non-insulin anti-diabetic drugs such as sulfonylureas, biguanides, thiazolidinediones, α-glucosidase inhibitors, Dipeptidyl peptidase 4 (DPP-4) inhibitors, and Sodium-glucose cotransporter-2 (SGLT2) inhibitors. 7 However, the use of anti-diabetic

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Traditional Medicinal Plants of Sri Lanka and Their Derivatives of Benefit to the Nervous System

Perera

Meedeniya

Chamikara

2021

Medicinal Herbs and Fungi

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Screening of Ethanolic Extract of Diospyros malabarica Desr. Bark for Anti-diabetic and Antioxidant Potential.

Cited by 5 publications

References 12 publications

A Comparative Study of Diospyros malabarica (Gaub) Extracts in Various Polarity-Dependent Solvents for Evaluation of Phytoconstituents and Biological Activities

A Comparative Study of Diospyros malabarica (Gaub) Extracts in Various Polarity-Dependent Solvents for Evaluation of Phytoconstituents and Biological Activities

Phytochemical Constituents, Anti-Diabetic and Antioxidant Activities of Methanol Extracts of Diospyros malabarica (Desr.) Kostel Leaves and Stem Bark

Traditional Medicinal Plants of Sri Lanka and Their Derivatives of Benefit to the Nervous System

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