Screening of Ethanolic Extract of <i>Borassus flabellifer Flowers for its Antidiabetic and Antioxidant Potential

Abstract

Ipomoea reniformis Chaos is claimed in Indian traditional medical practice to be useful in the treatment of epilepsy and neurological disorders. In the present study, pretreatment effect of methanolic extract of Ipomoea reniformis on epilepsy and psychosis was evaluated in rodents using standard procedures. Besides evaluating epileptic and behavioral parameters, neurotransmitters such as Gamma-Amino Butyric Acid (GABA) in epilepsy and in psychosis dopamine, noradrenaline and serotonin contents in the rodent brain were estimated. The extract pretreatment reduced maximal electro shock; Isoniazid (INH) and Pentylenetetrazole (PTZ) induced seizures and also significantly inhibited the attenuation of brain GABA levels by INH and PTZ in mice. These results suggested that the observed beneficial effect in epilepsy may be by enhancing the GABAergic system. The test drug also inhibited the apomorphine induced climbing and stereotyped behavior and showed significantly reduced levels of brain dopamine, noradrenaline and serotonin which may be due to blocking of central dopaminergic, noradrenergic and serotonergic pathways or by enhancing the GABAergic system. The results obtained in present study suggest that the title plant possesses antiepileptic and antipsychotic activities in rodents.

Hydrogel Containing Borassus flabellifer L. Male Flower Extract for Antioxidant, Antimicrobial, and Anti-Inflammatory Activity

“…In addition, part of B. flabellifer contained different amounts of total flavonoids. The total flavonoid content in quercetin equivalent in B. flabellifer flower was significantly higher than the root [ 18 ].…”

“…Tusskorn et al showed that the male flower of B. flabellifer extracted by ethyl acetate and chloroform had the IC 50 values of 287.03 ± 6.90 and >1000 µg/mL, respectively [ 16 ]. Kavatagimath et al reported that the B. flabellifer male flower extracted by 95% ethanol and butylated hydroxytoluene had the IC 50 values of 460 and 419 µg/mL, respectively [ 18 ]. The IC 50 values of B. flabellifer male flower ethanolic extract reported in our study showed a significantly lower value indicating that the male flower ethanolic extract had a superior antioxidant activity compared with the other solvents.…”

“…The polyphenolic compounds can degrade upon drying, extraction, and long-term storage [ 19 ]. According to the Kavatagimath et al report, the extraction temperature might affect the stability of phenolic compounds, which are the active pharmaceutical ingredient for antioxidant activity [ 18 ]. The high temperature during continuous hot extraction using Soxhlet apparatus may result in degradation of the phenolic compounds and reduced antioxidant activity observed by the DPPH method [ 20 ].…”

In Vitro Antibacterial, Anticancer and Antidiabetic Potential of Freeze-dried Aqueous Borassus flabellifer L. Seed Powder Extract

“…Medicinal fruits stand a great chance in controlling blood sugar levels and exerting antidiabetic activity due to the pharmacologically active phytoconstituents present in them [29] . While looking for natural options, researchers stumbled upon the ethanolic extract of B. flabellifer flowers and observed a decrease in the blood glucose levels when administered to alloxan induced diabetic rats [30] .…”

Effect of Plant Stage and Solvent Extraction on Catechin Contents in Borrasus flabellifer L. Male Flower

“…6 Previous studies have reported the presence of phytochemical compounds and their corresponding bioactivities in various organs of B. flabellifer L. For instance, the root contains alkaloids, flavonoids, and tannins with antimicrobial, antioxidant, and anti-inflammatory activities, 7 while the flowers contain flavonoids, saponins, tannins, and phenolics with antioxidant and anti-inflammatory activities. 8,9 However, it is difficult to find studies on other specific compounds in this plant. Therefore, an attempt to screen the phytochemicals in this plant using the High-Performance Liquid Chromatography (HPLC) method was conducted.…”