Organometallic compounds conjugates play a vital role in new drug discovery, in which Schiff base is useful as a ligand in consideration with different metals. Schiff base mostly encouraged due to its versatile activity due to the presence of a unique Imine (C=N) group. An attempt has been taken to synthesize a Schiff base by using salicylaldehyde and ethylene diamine which further design for the incorporation of salts of Cu, Ni and Zn metals separately. The ligand and its metal complexes have been carried out several characterization studies like elemental analysis, molar conductance, UV, IR and H 1 NMR. DPPH antioxidant potential and antimicrobial effect against four species Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus have been done with the ligand and all its metal complexes. The result revealed that metal incorporation in the Schiff base ligand enhanced the antioxidant potential as well as remarkable antimicrobial effect.
In food industries worldwide, food processing methods are tremendously needful to meet the present
consumer’s demands. There are continuously increasing efforts to develop food preservatives by
avoiding chemicals for which natural sources are the only alternative. Morninga oleifera (Moringaceae)
is highly nutrious and medicinaly valued plant which will be detoriate with the microbial and
environmental factors. The preservation of food materials is really challenged without using the chemical
preservatives. The use of spice property of ginger and garlic has a characteristic pungent, hot, flavour
that mellows and sweetens considerably with cooking. They both have the radical scavenging activity
otherwise considered ideal antioxidants beneficial in many reported diseases including the antifungal,
antibacterial and antiviral and antiparasitic agents. Therefore, the present study has been undertaken
to investigate the popularly used ginger and garlic in the management of antimicrobial activity of
leaves of Morninga oleifera by in vitro as well as in silico approaches.
The free and polymer anchored complexes of iron and cobalt [3-MHBdMBn-M and P-3-MHBdMBn-M], supported by ONNO-tetradentate Schiff-base ligands are prepared by the reactions of metal solution with one molar equivalent of unsupported 3-MHBdMBn (N, N'-bis (2-hydroxy-3-methylbenzaldehyde) 4-Methylbenzene-1,2-diamine) or polymer supported (P-3-MHBdMBn) Schiff-base ligands in methanol. The structural study reveals that iron(III) complex of 3-MHBdMBn Schiff base is octahedral in geometry, whereas, cobalt(II) ions complexes is square planar. Complexation of metal ions increased the thermal stability of 3-MHBdMBn Schiff base. The catalytic activities of metal complexes towards the oxidation of phenol are investigated in the presence of hydrogen peroxide. Experimental results indicate that the reactivity of P-3-MHBdMBn-M is dramatically affected by the polymer support over 3-MHBdMBn-M and iron complexes have greater activity than the cobalt analogue.
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