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Background: Rhizomes of Heliconia rostrata (Heliconiaceae) has antiophidic, in vitro antioxidant and antibacterial activity. Aim: Extracts of rhizome and inflorescence of H. rostrata were studied to test their angiogenesis and anti-angiogenesis effect using ex-ovo chorioallantoic membrane (CAM) assay. Methods: Dried defatted rhizomes of H. rostrata were macerated using ethanol, methanol and water to obtain rhizome ethanol extract (REE), rhizome methanol extract (RME) and rhizome aqueous extract (RAE), respectively. Similarly, defatted dried inflorescence of H. rostrata was macerated with water to obtain inflorescence aqueous extract (FAE). Dried extracts were used in 0.50, 1.00, 1.50, 2.00 and 2.50 mg dose applied in 3mm diameter filter paper for the CAM study. Pictorial as well as a semi-quantitative method was used to evaluate the antiangiogenic effect of the extracts in different doses. Changes before at 0h and after treatment at 4 h were compared. Results: The CAM treated with RAE and FAE showed anti-angiogenic effect at 2.50 mg dose per paper. While, CAM treated with REE and RME showed anti-angiogenic effect at 1.50 mg dose per paper. Semi-quantitative evaluation done by five different evaluators (blindly) suggested RME to be the strongest among the extracts in terms of the anti-angiogenic effect. No angiogenic effect is seen. Conclusion: But the higher doses at which the anti-angiogenic effect is seen suggests that Heliconia rostrata may be considered neither angiogenic nor anti-angiogenic.

Organometallic compounds conjugates play a vital role in new drug discovery, in which Schiff base is useful as a ligand in consideration with different metals. Schiff base mostly encouraged due to its versatile activity due to the presence of a unique Imine (C=N) group. An attempt has been taken to synthesize a Schiff base by using salicylaldehyde and ethylene diamine which further design for the incorporation of salts of Cu, Ni and Zn metals separately. The ligand and its metal complexes have been carried out several characterization studies like elemental analysis, molar conductance, UV, IR and H 1 NMR. DPPH antioxidant potential and antimicrobial effect against four species Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus have been done with the ligand and all its metal complexes. The result revealed that metal incorporation in the Schiff base ligand enhanced the antioxidant potential as well as remarkable antimicrobial effect.

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The purpose of this study is to evaluate the acute oral toxicity study of the Turmeric based herbal product in the sprague dawley rats.  Acute oral toxicity refers to those adverse effects occurring following oral administration of a single dose of a substance, or multiple doses given within 24 hours. The LD50 value, defined as the statistically derived dose that, when administered in an acute toxicity test, is expected to cause death in 50% of the treated animals in a given period, is currently the basis for toxicologic classification of chemicals. The test item, Turmeric based herbal product was evaluated for Acute Oral Toxicity in Sprague Dawley Rats as per the OECD Guideline No. 425 -Acute Oral Toxicity - Up-and-Down Procedure. Based on the results, it may be concluded that the LD50 of test item is >5000 mg/kg body weight as per OECD Guideline No. 425-Acute Oral Toxicity-Up-and-Down Procedure.