Antioxidant and Anti-Microbial Activity Study of Synthesized Copper, Nickel and Zinc Metals Schiff Base Derivative of Salicylaldehyde

Abstract

Organometallic compounds conjugates play a vital role in new drug discovery, in which Schiff base is useful as a ligand in consideration with different metals. Schiff base mostly encouraged due to its versatile activity due to the presence of a unique Imine (C=N) group. An attempt has been taken to synthesize a Schiff base by using salicylaldehyde and ethylene diamine which further design for the incorporation of salts of Cu, Ni and Zn metals separately. The ligand and its metal complexes have been carried out several characterization studies like elemental analysis, molar conductance, UV, IR and H 1 NMR. DPPH antioxidant potential and antimicrobial effect against four species Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus have been done with the ligand and all its metal complexes. The result revealed that metal incorporation in the Schiff base ligand enhanced the antioxidant potential as well as remarkable antimicrobial effect.

New Tetra-dentate Schiff Base Ligand N2O2 and Its Complexes with Some of Metal Ions: Preparation, Identification, and Studying Their Enzymatic and Biological Activities

“…The poly or tetra-dentate Schiff base ligands with N 2 O 2 coordination system and their metallic complexes have been also gained the attention of scientific researchers due to excellent complexation ability, so it is used in analytical field to remove of some heavy pollutant metals (such as Hg(II) and Ag(I)) from liquid media, in selective separation and purification of Cu(II) ions from mixtures, used as optical sensors for the determination of copper ion, and used as modified electrodes sensor of the aliphatic alcohols [7][8][9][10][11] . In biological fields, the complexes of N 2 O 2 Schiff base ligands were used as anti-bacterial against gram negative and gram-positive types, antifungal, anticancer, antioxidant, as enzyme inhibitors, antiinflammatory, and DNA-cleavage in presence of hydrogen peroxide [12][13][14][15][16][17][18][19][20] . In catalytic reactions the tetra-dentate Schiff base ligands have been used for controlling the radical polymerization, as catalysts for oxidation of phenol, a good catalytic for increasing the chain length of the imine compartment, used as active catalyst for Suzuki and Heck reactions of Iodobenzene, used to catalyze the aerobic oxidation of catechol derivative, and used as catalyst for conversing of Naphthalene derivative to derivative of Naphthoquinone (K 3 vitamin), in green synthesis process [21][22][23][24][25][26] .…”