The purpose of this study is to evaluate the acute oral toxicity study of the Turmeric based herbal product in the sprague dawley rats. Acute oral toxicity refers to those adverse effects occurring following oral administration of a single dose of a substance, or multiple doses given within 24 hours. The LD50 value, defined as the statistically derived dose that, when administered in an acute toxicity test, is expected to cause death in 50% of the treated animals in a given period, is currently the basis for toxicologic classification of chemicals. The test item, Turmeric based herbal product was evaluated for Acute Oral Toxicity in Sprague Dawley Rats as per the OECD Guideline No. 425 -Acute Oral Toxicity - Up-and-Down Procedure. Based on the results, it may be concluded that the LD50 of test item is >5000 mg/kg body weight as per OECD Guideline No. 425-Acute Oral Toxicity-Up-and-Down Procedure.
: Owing to their unique characteristics and diverse surface activities, gold nanoparticles (AuNPs) have been widely used in various fields of biology. The ease with which AuNPs can be functionalized makes it a useful platform for nanobiological assemblies containing oligonucleotides, antibodies, and proteins. AuNPs bioconjugates have also emerged as an interesting candidate for the development of novel biomaterials for the study of biological systems. AuNPs' flexibility has made them valuable in a variety of biomedical applications. The binding of analytes to AuNPs can change the physicochemical features of AuNPs, such as surface plasmon resonance, conductivity, and redox activity, resulting in observable signals in diagnostics. AuNPs can also be used as a therapeutic platform because of their large surface area, which allows for a dense presentation of multifunctional moieties (e.g., drugs and targeting agents). We present a brief summary of green synthesis, characteristics, and applications of gold nanoparticles in this paper, as well as their translational potential.
Traditional medicine has a lot to give towards the world’s health, especially now that limits to conventional pharmacology has occurred. New scientific methodologies may spark a rebirth in global health research and development if rich and developing countries pooled their research capacities with inequitable collaborations. The Cassytha Filiformis has many medicinal uses. It is a parasite plant that has been used for medicinal purposes and other ornamental purposes in many parts of the world, and has found employment in Siddha, European, Ayurveda and Chinese folk medicine. In this review, the ethnobotany, phytochemistry and pharmacological benefits of Cassytha filiformis are discussed.
Heterocyclics are flexible chemicals found in practically all-natural products and synthesized organic compounds, and are frequently linked to one biological action or another. The thiazoles, coumarins and benzothiazoles are among the most common heterocyclics used till date for multi-functional activity. They have a wide range of biological functions and can be found in a variety of bioactive compounds and medications, including vitamin thiamine, sulfathiazole [antimicrobial drug], ritonavir [antiretroviral drug], abafungin [antifungal drug], and tiazofurin [] [antineoplastic drug]. These drugs are just a mirror of a huge library of biological compounds. The thiazole and benzothiazole moiety is common in natural compounds, whereas the coumarin moiety is used for preparing hybrid molecules. The literature reports on thiazoles, counmarin and benzothiazoles with various biological activity are presented in this review.
Microencapsulation is a process in which active substances are coated by extremely small capsules. It is a new technology that has been used in the cosmetics industry as well as in the pharmaceutical, agrochemical and food industries, being used in flavours, acids, oils, vitamins, microorganisms, among others. This paper provides an UpToDate review of different microencapsulation methods and polymers used specifically for Celecoxib drug. As Celecoxib is poorly soluble in water, there are several methods used to improve solubility and bioavailability using various polymers. The different microencapsulation methods along with different polymers were studied and given a comprehensive review. There are several NSAIDs which are used for pain management and Celecoxib is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation, and menstrual symptoms. There are many techniques available that can be used to fabricate microcapsules based on desired characteristics, and applications of the final microcapsule formulation. For Celecoxib microencapsulation, Spray drying techniques are widely used method for the research studies. some of the advantages of spray-drying include its ability to be fully automated and continuous.
Background: Currently, Convalescent plasma (CP)is considered a favorable treatment option for moderate to critically ill Covid-19 patients. But there were very few systematic reviews focused on the effect of CP on clinical parameters. As a result, we undertook this systematic review to learn more about the safety and clinical benefits of convalescent plasma therapy over standard treatment (control). Methodology: We searched Pub Med, Embase and other bibliographic databases to find relevant articles between December 2019 and February 2021 and identified 10 relevant articles which compared CP therapy taken in addition to standard medication with the Control group(who received standard medication). Two independent reviewers examined all full-text articles and extracted the required information intoa predesigned proforma. Forest plots were drawn using RevMan v.5, a statistical tool offered by the Cochrane database to estimate the pooled effect. Results: The results of meta-analysis using a random effect model indicated a significant reduction in mortality rate in CP (about 27% risk reduction), a reduced length of hospital stay in about 2 days (Weighted Mean Difference: -2.53, 95% CI, -7.20 to -2.14, P<0.0001), less time to improve clinical symptoms in about 4 days (pooled mean; CP:10.82 days vs Control:15.14 days). C-Reactive Protein (CRP) concentration levels (mg/L) were well controlled with the control group than the CP group and significant changes in lymphocytes and D-dimer values were not observed after CP treatment. It was also found that no difference between CP transfusion and control was seen in improving the oxygen saturationlevels. Conclusion: CP transfusion can be considered safe and showed a significant reduction in mortality and possible benefits in clinical improvement. Patients on CP therapy had no significant benefits in improving inflammatory markers such as CRP, lymphocytes, D-dimer, or oxygen saturation levels over standard drug therapy, according to meta-analysis data.
Alzheimer’s disease (AD) is a progressive neurological disorder. Recent studies show that AD is the most common cause of dementia. There are several symptomatic treatments available to counterbalance the neurotransmitter disturbance. Currently, cholinesterase inhibitors are available for the treatment of mild to moderate AD. In addition to that, memantine (an N-methyl-D-aspartate receptor non-competitive antagonist) is also available for moderate to severe AD. Poor blood-brain barrier permeability is a limitation of existing drugs. These drugs may slow the disease progression, but there are chances of reoccurrence of the disease. Several medicinal plants such as Jasminum sambac, Rosmarinus officinalis, Eucalyptus globulus, Nigella sativa, and Acorus gramineus are reported to have neuroprotective effects. Salvia officinalis has cholinergic binding properties. Ginger root extract may prevent behavioral dysfunction in AD. Extensive research on these plants should be carried out. Drug delivery systems such as lipid nanoparticles, polymer nanoparticles, nano-micelles, nano-gels, liposomes, phytosomes, etc., could significantly improve the pharmacokinetics, stability, efficacy and reduce the side effects. Phytosomes have the advantage over other drug delivery systems to selectively target the drugs into the brain. In contrast to traditional approaches, polar phytoconstituents loaded phytosomes are more bioavailable on the site of brain tissue, as they can easily go for systemic circulation crossing the Blood-Brain Barrier (BBB). Phytosomes have a low hazard profile as toxicological outcomes are negligible and assure duration of action at a low-risk profile due to upgraded absorption of the active constituents. In addition to this, the improved pharmacodynamic properties of phytosomes make them suitable for the treatment of neurological disorders.
Covaxin and Covishield have been granted approval for emergency medical use in India due to the severity of COVID-19. Both vaccines are safe and effective and have a good immunogenic response. There is no difference between Covaxin and Covishield in terms of dosages and both can be administered as 0.5 mL (containing 6 mg of virus antigen for Covaxin and 5×1010 virus particles for Covishield) in the upper arm region. Covaxin and Covishield are designed for a two dose schedule, and it is advised that the second dose of Covaxin be administered 4-6 weeks after the first dose while 12-16 weeks after the first dose for Covishield. These vaccines may have several side effects such as swelling and itching at the injection site, joint pain, dizziness, headache, allergic reaction, increased heartbeat, and fever. Appropriate counselling and suggestion should be provided for any symptoms associated with vaccination so that post-vaccinated issues can be managed. Physician and community pharmacists may play a vital role in the management of adverse drug event associated with vaccines.
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