In excising basal and squamous cell carcinomata, the surgical margin that is wide enough to completely remove the tumor an acceptable percentage of the time and narrow enough to minimize removal of excessive normal tissue must be selected. This task can be reliably accomplished with comprehensive knowledge of factors that affect subclinical tumor extension such as tumor appearance, diameter, histology, location, treatment status, and, in the case of squamous cell carcinoma, vertical invasion depth and involvement of subcutaneous fat. Information regarding these factors along with specific recommendations about excisional margins for basal cell and squamous cell carcinomata is presented.
Skin manifestations of systemic disease and malignancy are protean. The recognition of a potentially paraneoplastic dermatosis as such must prompt an investigation for occult malignancy. Lack of familiarity with cutaneous clues of internal malignancy may delay diagnosis and treatment of cancer. It is important to consider a paraneoplastic process in the differential diagnosis of a number of eruptive and treatment-resistant dermatoses. These dermatoses may be the first sign of an occult neoplasm. Their recognition may assist in cancer detection and the swift induction of appropriate therapy.
Carbon dioxide laser vaporization of epidermal nevi provides good clinical effect and offers unique advantages for the treatment of these lesions, including effective intraoperative hemostasis with excellent lesional visualization. It is also possible to treat widespread areas in one laser treatment session. While the results of this series clearly show the benefit of CO2 laser treatment, epidermal nevi may not always respond so favorably, due in part to the variability in their depths of involvement.
The generally good tolerability and relative safety of bupropion-SR makes a trial of this agent worthwhile in patients with atopic dermatitis or psoriasis who have failed treatment with more conventional medications. Normalization by bupropion of potentially causative neuroendocrine, immunologic, or catecholaminergic abnormalities in both of these dermatologic disorders is a possible mechanism of action for the observed salutary effects of this drug on our subjects' skin disease.
Introduction:
Cellulite has always been a difficult condition for patients and cosmetic physicians to treat. Even if improvement is made in the appearance of cellulite, no machine or topical treatment exists that can provide long-term results in the treatment of cellulite. We evaluated a technique that increases lymphatic drainage and vascular permeation to assist in decreasing the appearance of cellulite.
Materials and Methods:
Sixteen female patients underwent 12 treatments with a device called Triactive, which has a triple-pronged mechanism of action consisting of low-level suction, diode laser, and contact cooling. We measured results by waist, hip, and thigh circumference as well as elasticity, thermography, and blinded photograph evaluations.
Results:
We found a small decrease in hip and thigh circumference as well as an increase in elasticity of the treated cellulite. Evaluation of the photographs yielded an overall 21% average improvement in the appearance of cellulite. There was no change in thermography data after treatments. Results were not present at 1 month.
Discussion:
The Triactive offers a method to temporarily decrease the appearance of cellulite. It appears that treatments must be continued to maintain results. Further study and larger patient groups are needed before this treatment can be recommended above other available treatments.
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