Treatment of Atopic Dermatitis and Psoriasis Vulgaris With Bupropion-SR: A Pilot Study

Modell, Jack G.; Boyce, Sarah; Taylor, Eric; Katholi, Charles R.

doi:10.1097/00006842-200209000-00017

Cited by 15 publications

(19 citation statements)

References 41 publications

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“…23 A more recent study examined the use of bupropion in the treatment of non-depressed patients with psoriasis or atopic dermatitis (AD). 24 This open-label study of 11 patients with psoriasis and 13 with AD (with no controls) used a 6-week intervention (150 mg/day for 3 weeks, then either 150 or 300 mg/day for 3 weeks) with a further 3 weeks of follow up. Three of the AD subjects and one of the psoriasis subjects dropped out (none because of side-effects).…”

Section: Potential Treatment Modalitiesmentioning

confidence: 99%

Psychiatric morbidity in psoriasis: A review

Russo¹,

Ilchef²,

2004

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Psoriasis is a common condition, affecting 1.5-2% of the population of industrialized countries. It is important for clinicians to be aware that psoriasis can have a substantial emotional impact on an individual, which is not necessarily related to the extent of skin disease. This review examines current literature addressing the psychological and emotional aspects of psoriasis. A literature search of the MEDLINE (1966-2002) and PsycINFO (1984-2002) computer databases and bibliographies was carried out. Papers selected for the review included English language reviews and all original research relevant to the topic, in the form of randomized controlled trials, cohort studies, case-control studies, cross-over and uncontrolled clinical trials, patient surveys, quality-of-life studies, case series and case reports. Despite significant shortcomings, the available prevalence studies showed uniformly high rates of psychopathology among psoriasis sufferers. The few intervention studies available are summarized and critically discussed. Psoriasis is associated with a variety of psychological problems, including poor self esteem, sexual dysfunction, anxiety, depression and suicidal ideation. The clinical severity of the psoriasis may not reflect the degree of emotional impact of the disease. A number of psychological interventions have shown promise in recent trials. It is important that clinicians consider the psychosocial aspects of this illness.

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Section: Potential Treatment Modalitiesmentioning

confidence: 99%

Psychiatric morbidity in psoriasis: A review

Russo¹,

Ilchef²,

2004

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“…We cannot precisely explain the reason for the high rate of RLS seen in patients with AD. However, although the exact aetiopathogenesis of these disorders remains unknown, the current literature hints at a possible association with a disruption in the balance between the dopaminergic and noradrenergic systems in the CNS 36,37 . Thus, it has been reported in the literature that bupropion, a dopamine reuptake inhibitor, brought about a marked recovery in a significant proportion of lesions in patients with severe and resistant AD and psoriasis, independent of emotional factors (without depression).…”

Section: Discussionmentioning

confidence: 99%

Increased frequency of restless legs syndrome in atopic dermatitis

Çiçek

Halisdemir

Dertioglu

et al. 2012

Clinical and Experimental Dermatology

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“…197,205,206 Beyond isolated case reports, only one small and uncontrolled trial demonstrated significant benefits of bupropion therapy in patients with atopic dermatitis or psoriasis. 207 Bupropion and gastrointestinal function or pain. Despite the potential role of dopamine and adrenergic signaling in the gastrointestinal tract, we have limited information about the effect of bupropion on gut function.…”

Section: Bupropion In Ibdmentioning

confidence: 99%

Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD

Thorkelson

Bielefeldt

Szigethy

2016

Inflammatory Bowel Diseases

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Antidepressant medications are frequently prescribed for depression, anxiety disorders, and chronic pain syndromes, but overall support for their efficacy is modest at best. Psychological interventions have growing support for having much more robust effects without the side effects of antidepressants and should be considered first-line treatment or at least an adjunct to psychotropic medications for these conditions.

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Treatment of Atopic Dermatitis and Psoriasis Vulgaris With Bupropion-SR: A Pilot Study

Cited by 15 publications

References 41 publications

Psychiatric morbidity in psoriasis: A review

Psychiatric morbidity in psoriasis: A review

Increased frequency of restless legs syndrome in atopic dermatitis

Empirically Supported Use of Psychiatric Medications in Adolescents and Adults with IBD

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