Paraneoplastic dermatoses

Abstract

Skin manifestations of systemic disease and malignancy are protean. The recognition of a potentially paraneoplastic dermatosis as such must prompt an investigation for occult malignancy. Lack of familiarity with cutaneous clues of internal malignancy may delay diagnosis and treatment of cancer. It is important to consider a paraneoplastic process in the differential diagnosis of a number of eruptive and treatment-resistant dermatoses. These dermatoses may be the first sign of an occult neoplasm. Their recognition may assist in cancer detection and the swift induction of appropriate therapy.

A Clinical Study of Paraneoplastic Dermatoses in Internal Malignancy

“…1,4,5 Three non-specific skin changes were found with increased predilection in patients with malignant diseases as compared to controls and those were acquired ichthyosis, generalised pruritus and herpes zoster. All the cases of acquired ichthyosis and generalised pruritus were common in Hodgkin's lymphoma as reported by other workers.…”

Signo de Leser-Trélat asociado a adenocarcinoma gástrico: Caso clínico

“…Atributos de los que carece la primera forma mencionada. Su patrón de distribución se ha descrito clásicamente como en "árbol de Navidad" 7,8 . Estas lesiones representan una proliferación benigna de queratinocitos inmaduros en relación a la explosión múltiple de mediadores inflamatorios en el proceso proliferativo del cáncer gástrico, las alteraciones en los niveles séricos de factores de crecimiento humano, incluyendo el TGF-alfa, TGF-beta, y factor de crecimiento epidermoide (EGF) han sido implicados en la patogénesis pero no probado.…”

Cutaneous manifestations of internal malignancies in a tertiary health care hospital of a developing country

“…In general, the histopathologic findings of the paraneoplastic dermatoses described in this study were similar to those reported worldwide. [1][2][3][4] In our study, the most frequent neoplasm associated with paraneoplastic dermatoses was NonHodgkin's lymphoma. The dermatoses associated with this type of lymphoma were paraneoplastic immunobullous dermatoses, lymphomatoid papulosis, edema-tous scarring vasculitic panniculitis, norwegian scabies, infective dermatitis, generalized pruritus and acquired ichthyosis.…”

“…They are the second most common paraneoplastic disease after the endocrinologic paraneoplastic syndromes. 1,2 Paraneoplastic dermatoses are characterized by a diverse range of cutaneous changes, some of which appear benign. Therefore, they may go unnoticed by the physician.…”

“…In fact, the first two criteria (major criteria) are sufficient to consider a dermatosis as paraneoplastic. [1][2][3][4] The frequency with which some benign dermatoses are associated with underlying malignancy suggests that this is not random; however in most cases it is difficult to demonstrate a cause-effect relationship with the primary tumor. The current literature suggests that these phenomena are the result of the interaction between the tumor, some mediator factors and the involved tissue.…”