L-Proline was utilized as an efficient organo-catalyst for the environmentally benign synthesis of 3-substituted coumarins by the Knoevenagel condensation of substituted 2-hydroxybenzaldehydes with reactive methylene compounds under solvent free conditions.
L-Proline is found as an effective catalyst for the one-pot four-component Hantzsch reaction to afford polyhydroquinoline derivatives (IV). The method is environmentally benign proceeds with high yields and allows an increased variation of substituents. -(KARADE*, N. N.; BUDHEWAR, V. H.; SHINDE, S. V.; JADHAV, W. N.; Lett.
Scolecite is one kind of natural zeolite. A three component Biginelli reaction using scolecite as a novel heterogeneous acid catalyst is demonstrated. The short reaction time, clean reaction conditions, consistent yields and minimum environmental effects are important features of the reaction.
A clean and simple synthesis of 6-amino-4-aryl-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles was accomplished in good to excellent yields via the one-pot three component condensation of 3-methyl-1-phenyl-2-pyrazolin-5-one, an aromatic aldehyde, and malononitrile catalysed by sulfamic acid in ethanol.
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