Scolecite as a Novel Heterogeneous Acid Catalyst for an Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Via Multi-component Biginelli Reaction

Abstract

Scolecite is one kind of natural zeolite. A three component Biginelli reaction using scolecite as a novel heterogeneous acid catalyst is demonstrated. The short reaction time, clean reaction conditions, consistent yields and minimum environmental effects are important features of the reaction.

Scolecite as an efficient heterogeneous catalyst for the synthesis of 2,4,5-triarylimidazoles

“…Scolecite [24] is a natural zeolite that is available worldwide, it is inexpensive, non-toxic and reusable and has Lewis and Bronsted acidic sites that permit it to act as a bi-functional heterogeneous catalyst in an eco-friendly manner.…”

“…In continuation to our work in synthesis of organic compounds using heterogeneous catalyst [24][25][26], herein, we report a very simple, fast and general method for the synthesis of 2,4,5-triarylimidazoles using natural scolecite as a catalyst. Our methodology offers several advantages including mild reaction conditions, cleaner reaction, high yield of products as well as a simple experimental and isolation procedures which make it a useful and attractive process for the synthesis of these compounds.…”

Recyclable Amberlyst-70 as a Catalyst for Biginelli Reaction: An Efficient One-Pot Green Protocol for the Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones

“…A truly heterogeneous catalyst such as montmorillonite KSF have been previously demonstrated for this reaction, but the reaction time (10-48 h) is relatively longer [35,36]. Recently, Shinde et al [37] reported the catalytic efficiency of the natural zeolite-Scolecite in acetonitrile medium. Joseph et al [38] evaluated the catalytic efficiency of Nafion NR-50 and Amberlyst-15 in acetonitrile medium under nitrogen atmosphere for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones.…”

Scolecite Catalyzed Facile and Efficient Synthesis of Polyhydroquinoline Derivatives through Hantzsch Multi-component Condensation

“…zeolite. 20 Green chemistry approaches are significant due to the reduction in byproducts, a reduction in waste produced and lowering of energy costs. The possibility of performing multi-component reactions with a natural heterogeneous catalyst could enhance their efficiency from an economic as well as ecological point of view.…”

“…20,21 We report here a convenient and efficient method for the synthesis of polyhydroquinoline derivatives using scolecite as a catalyst (Scheme 1).…”