Scolecite Catalyzed Facile and Efficient Synthesis of Polyhydroquinoline Derivatives through Hantzsch Multi-component Condensation

Abstract

A facile and efficient synthetic route has been developed for the polyhydroquinoline via four component reactions of aldehydes, dimedone, ethyl acetoacetate and ammonium acetate in the presence of catalytic amount of scolecite in ethanol at 70 o C through Hantzsch reaction. This method gives remarkable advantages such as simple work-up procedure, environmentally friendly, inexpensive, non-toxic and recyclable catalyst, shorter reaction time along with excellent yields.

MgO Supported Al2O3 Oxide: A New, Efficient, and Reusable Catalyst for Synthesis of Chalcones

“…Hence, there is a need for simple and clean reaction chemistry in order to increase the atom-economy of the process. So far the use of mixed metal oxide as a catalyst for the reaction has not been explored and in continuation of our interest in a solid acid-base catalyst for organic transformations [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60], we herein developed a green, simple and convenient method for the synthesis of chalcones from a substituted aldehyde and acetophenone in ethanol under reflux conditions (Scheme 1).…”

Synergistic effect of natural chickpea leaf exudates acids in heterocyclization: a greener protocol for benzopyran synthesis

“…Different natural materials are used as solid support as well as catalysts in a large number of reactions promoting the formation of final products. Natural materials such as different plant parts such as fruits, root extracts [26][27][28][29][30][31][32], clays [33,34], zeolites [35,36] and enzymes [37,38] are used effectively in numerous chemical transformations.…”